Evidence map›Paper›PMID 31399545›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

ARF6 and AMAP1 are major targets of

Shigeru Hashimoto, Shotaro Furukawa, Ari Hashimoto, Akio Tsutaho, Akira Fukao, Yurika Sakamura, Gyanu Parajuli, Yasuhito Onodera, Yutaro Otsuka, Haruka Handa and 9 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed
11.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 159 citations in OpenAlex.

  1. Review
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  4. Review
  5. Intracellular PD-L1: Functions, Regulation, and Therapeutic Implications.International journal of biological sciences · 2026
    Review
  6. Review
  7. Article
  8. Article
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  10. Precision immune regulation in KRAS-mutated cancers: the final piece of the puzzle?Journal of experimental & clinical cancer research : CR · 2025
    Review
  11. Article
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  13. Article
  14. Review
  15. Review
  16. Article
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  19. Article
  20. Review

35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 2 countries.

Shigeru HashimotoDepartment of Molecular Biology, Hokkaido University Graduate School of Medicine, 060-8638 Sapporo, Japan.
Shotaro FurukawaDepartment of Molecular Biology, Hokkaido University Graduate School of Medicine, 060-8638 Sapporo, Japan.
Ari HashimotoDepartment of Molecular Biology, Hokkaido University Graduate School of Medicine, 060-8638 Sapporo, Japan.
Akio TsutahoDepartment of Molecular Biology, Hokkaido University Graduate School of Medicine, 060-8638 Sapporo, Japan.
Akira FukaoLaboratory of Biochemistry, Graduate School of Pharmaceutical Sciences, Kindai University, 577-8502 Osaka, Japan.
Yurika SakamuraLaboratory of Biochemistry, Graduate School of Pharmaceutical Sciences, Kindai University, 577-8502 Osaka, Japan.
Gyanu ParajuliLaboratory of Immune Regulation, World Premier International Research Center Initiative Immunology Frontier Research Center, Osaka University, 565-0871 Osaka, Japan.
Yasuhito OnoderaDepartment of Molecular Biology, Hokkaido University Graduate School of Medicine, 060-8638 Sapporo, Japan.
Yutaro OtsukaDepartment of Molecular Biology, Hokkaido University Graduate School of Medicine, 060-8638 Sapporo, Japan.
Haruka HandaDepartment of Molecular Biology, Hokkaido University Graduate School of Medicine, 060-8638 Sapporo, Japan.ORCID 0000-0002-8557-7479
Tsukasa OikawaDepartment of Molecular Biology, Hokkaido University Graduate School of Medicine, 060-8638 Sapporo, Japan.
Soichiro HataDepartment of Molecular Biology, Hokkaido University Graduate School of Medicine, 060-8638 Sapporo, Japan.
Yoshihiro NishikawaDepartment of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 606-8507 Kyoto, Japan.ORCID 0000-0002-1113-6937
Yusuke MizukamiDivision of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, 078-8510 Asahikawa, Japan.ORCID 0000-0002-1068-7024
Yuzo KodamaDepartment of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 606-8507 Kyoto, Japan.
Masaaki MurakamiDivision of Molecular Psychoimmunology, Institute for Genetic Medicine and Graduate School of Medicine, Hokkaido University, 060-0815 Sapporo, Japan.
Toshinobu FujiwaraLaboratory of Biochemistry, Graduate School of Pharmaceutical Sciences, Kindai University, 577-8502 Osaka, Japan.
Satoshi HiranoDepartment of Gastroenterological Surgery II, Hokkaido University Graduate School of Medicine, 060-8638 Sapporo, Japan.
Hisataka SabeDepartment of Molecular Biology, Hokkaido University Graduate School of Medicine, 060-8638 Sapporo, Japan; sabeh@med.hokudai.ac.jp.
Hokkaido University · JPKindai University · JPKyoto University · JPAsahikawa Medical University · JPOsaka International University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although

Indexed as

ADP-Ribosylation Factor 6ADP-Ribosylation FactorsB7-H1 AntigenBinding SitesBiomarkers, TumorCell Line, TumorGene Expression Regulation, NeoplasticHumansImmune EvasionImmunohistochemistryModels, MolecularMutationPancreatic NeoplasmsPrognosisProtein BindingProto-Oncogene Proteins p21(ras)ADP-Ribosylation Factor 6ADP-Ribosylation FactorsARF6 protein, humanArf6 protein, mouseB7-H1 AntigenBiomarkers, TumorCD274 protein, humanKRAS protein, humanProto-Oncogene Proteins p21(ras)Receptors, Platelet-Derived Growth FactorRNA, MessengerTP53 protein, humanTumor Suppressor Protein p53ARF6mevalonate pathwaymRNA translationpancreatic driver oncogenesPD-L1

Identifiers

PMID31399545
PMCPMC6717289
OpenAlexW2967470918

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.