Evidence map›Paper›PMID 31399474›Full record

ArticleDevelopment (Cambridge, England)2019

Robust Wnt signaling is maintained by a Wg protein gradient and Fz2 receptor activity in the developing

Varun Chaudhary, Swapnil Hingole, Jana Frei, Fillip Port, David Strutt, Michael Boutros

Abstract read
In one paragraph

Article in Development (Cambridge, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Article
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  9. Article
  10. Understanding and manipulating extracellular behaviors of Wnt ligands.In vitro cellular & developmental biology. Animal · 2024
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. The wing imaginal disc.Genetics · 2022
    Article
  17. Review
  18. Early patterning followed by tissue growth establishes distal identity inFrontiers in cell and developmental biology · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Varun ChaudharyGerman Cancer Research Center (DKFZ), Division Signaling and Functional Genomics and Department of Cell and Molecular Biology, Medical Faculty Mannheim, Heidelberg University, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany m.boutros@dkfz.de varun.c@iiserb.ac.in.ORCID 0000-0001-9604-4806
Swapnil HingoleDepartment of Biological Science, Indian Institute of Science Education and Research Bhopal, Bhopal Bypass Road, Bhauri, Bhopal 462066, India.
Jana FreiGerman Cancer Research Center (DKFZ), Division Signaling and Functional Genomics and Department of Cell and Molecular Biology, Medical Faculty Mannheim, Heidelberg University, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany.
Fillip PortGerman Cancer Research Center (DKFZ), Division Signaling and Functional Genomics and Department of Cell and Molecular Biology, Medical Faculty Mannheim, Heidelberg University, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany.
David StruttDepartment of Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK.
Michael BoutrosGerman Cancer Research Center (DKFZ), Division Signaling and Functional Genomics and Department of Cell and Molecular Biology, Medical Faculty Mannheim, Heidelberg University, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany m.boutros@dkfz.de varun.c@iiserb.ac.in.ORCID 0000-0002-9458-817X

Funding

Wellcome Trust 210630/Z/18/Z
6 · The paper itself

Abstract

Wnts are secreted proteins that regulate cell fate during development of all metazoans. Wnt proteins were proposed to spread over several cells to activate signaling directly at a distance. In the

Indexed as

AnimalsDrosophila melanogasterDrosophila ProteinsFrizzled ReceptorsMembrane GlycoproteinsWings, AnimalWnt1 ProteinWnt Signaling PathwayDrosophila ProteinsFrizzled Receptorsfz2 protein, DrosophilaMembrane GlycoproteinsNrt protein, Drosophilawg protein, DrosophilaWnt1 ProteinDrosophilaFrizzledFz2Morphogen gradient formationProtein secretionWgWing epitheliumWnt

Identifiers

PMID31399474
PMCPMC6703709

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.