Evidence map›Paper›PMID 31399401›Full record

ArticleBlood advances2019

Combined deficiency of RAB32 and RAB38 in the mouse mimics Hermansky-Pudlak syndrome and critically impairs thrombosis.

Alicia Aguilar, Josiane Weber, Julie Boscher, Monique Freund, Catherine Ziessel, Anita Eckly, Stéphanie Magnenat, Catherine Bourdon, Béatrice Hechler, Pierre H Mangin and 3 more

Open access · goldAbstract read
In one paragraph

Article in Blood advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Alicia AguilarUniversité de Strasbourg, INSERM, Etablissement Français du Sang Grand Est, BPPS UMR-S 1255, Fédération de Médecine Translationnelle de Strasbourg, Strasbourg, France.
Josiane WeberUniversité de Strasbourg, INSERM, Etablissement Français du Sang Grand Est, BPPS UMR-S 1255, Fédération de Médecine Translationnelle de Strasbourg, Strasbourg, France.
Julie BoscherUniversité de Strasbourg, INSERM, Etablissement Français du Sang Grand Est, BPPS UMR-S 1255, Fédération de Médecine Translationnelle de Strasbourg, Strasbourg, France.
Monique FreundUniversité de Strasbourg, INSERM, Etablissement Français du Sang Grand Est, BPPS UMR-S 1255, Fédération de Médecine Translationnelle de Strasbourg, Strasbourg, France.ORCID 0000-0003-2128-8114
Catherine ZiesselUniversité de Strasbourg, INSERM, Etablissement Français du Sang Grand Est, BPPS UMR-S 1255, Fédération de Médecine Translationnelle de Strasbourg, Strasbourg, France.
Anita EcklyUniversité de Strasbourg, INSERM, Etablissement Français du Sang Grand Est, BPPS UMR-S 1255, Fédération de Médecine Translationnelle de Strasbourg, Strasbourg, France.
Stéphanie MagnenatUniversité de Strasbourg, INSERM, Etablissement Français du Sang Grand Est, BPPS UMR-S 1255, Fédération de Médecine Translationnelle de Strasbourg, Strasbourg, France.
Catherine BourdonUniversité de Strasbourg, INSERM, Etablissement Français du Sang Grand Est, BPPS UMR-S 1255, Fédération de Médecine Translationnelle de Strasbourg, Strasbourg, France.
Béatrice HechlerUniversité de Strasbourg, INSERM, Etablissement Français du Sang Grand Est, BPPS UMR-S 1255, Fédération de Médecine Translationnelle de Strasbourg, Strasbourg, France.
Pierre H ManginUniversité de Strasbourg, INSERM, Etablissement Français du Sang Grand Est, BPPS UMR-S 1255, Fédération de Médecine Translationnelle de Strasbourg, Strasbourg, France.
Christian GachetUniversité de Strasbourg, INSERM, Etablissement Français du Sang Grand Est, BPPS UMR-S 1255, Fédération de Médecine Translationnelle de Strasbourg, Strasbourg, France.ORCID 0000-0003-1303-4210
François LanzaUniversité de Strasbourg, INSERM, Etablissement Français du Sang Grand Est, BPPS UMR-S 1255, Fédération de Médecine Translationnelle de Strasbourg, Strasbourg, France.ORCID 0000-0002-5802-4748
Catherine LéonUniversité de Strasbourg, INSERM, Etablissement Français du Sang Grand Est, BPPS UMR-S 1255, Fédération de Médecine Translationnelle de Strasbourg, Strasbourg, France.ORCID 0000-0002-8597-9929
Inserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The biogenesis of lysosome related organelles is defective in Hermansky-Pudlak syndrome (HPS), a disorder characterized by oculocutaneous albinism and platelet dense granule (DG) defects. The first animal model of HPS was the fawn-hooded rat, harboring a spontaneous mutation inactivating the small guanosine triphosphatase

Indexed as

Genetic Predisposition to DiseaseAnimalsBlood PlateletsDisease Models, AnimalGenetic Association StudiesHermanski-Pudlak SyndromeHumansMiceMice, KnockoutMutationPhenotypePlatelet CountPlatelet Function Testsrab GTP-Binding ProteinsRatsThrombosisRab32 protein, mouseRab38 protein, mouserab GTP-Binding Proteins

Identifiers

PMID31399401
PMCPMC6693013
OpenAlexW2967781016

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.