ArticleImmunity2019
Programming of Distinct Chemokine-Dependent and -Independent Search Strategies for Th1 and Th2 Cells Optimizes Function at Inflamed Sites.
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Article in Immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
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Who cites it
34 citing papers in PubMed, 51 citations in OpenAlex.
- Increasing Filamins A and B in Th2 Lymphocytes as a Therapeutic Opportunity to Attenuate Airway Inflammation in Mice.Allergy · 2026Article
- S1P induces bleb-based T cell motility via S1PR1-dependent activation of RhoA and WNK1.bioRxiv : the preprint server for biology · 2025Article
- Development and validation of a perinatal risk prediction model for recurrent respiratory tract infections in moderate-to-late preterm infants: a retrospective cohort study.BMC pediatrics · 2025Article
- Nodal Expansion, Tumor Infiltration and Exhaustion of Neoepitope-Specific Th Cells After Prophylactic Peptide Vaccination and Anti-CTLA4 Therapy in Mouse Melanoma B16.International journal of molecular sciences · 2025Article
- Tissue-Resident Th2 Cells in Type 2 Immunity and Allergic Diseases.Immunological reviews · 2025Review
- Omalizumab Treated Urticaria Patients Display T Cell and Thrombocyte-Associated Gene Regulation.Immunity, inflammation and disease · 2025Article
- Targeting immune cell migration as therapy for inflammatory disease: a review.Frontiers in immunology · 2025Review
- Fine-tuning levels of filamins a and b as a specific mechanism sustaining Th2 lymphocyte functions.Nature communications · 2024Article
- T cells use focal adhesions to pull themselves through confined environments.The Journal of cell biology · 2024Article
- Migration of human T cells can be differentially directed by electric fields depending on the extracellular microenvironment.iScience · 2024Article
- Site-specific regulation of Th2 differentiation within lymph node microenvironments.The Journal of experimental medicine · 2024Article
- Platelet-derived microparticles adoptively transfer integrin β3 to promote antitumor effect of tumor-infiltrating T cells.Oncoimmunology · 2024Article
- T cells Use Focal Adhesions to Pull Themselves Through Confined Environments.bioRxiv : the preprint server for biology · 2023Article
- Th2 cells infiltrating high-grade serous ovarian cancer: a feature that may account for the poor prognosis.Journal of gynecologic oncology · 2023Article
- Review
- An αvβ3 integrin checkpoint is critical for efficient TNature immunology · 2023Article
- Chemokines and chemokine receptors in Behçet's disease.Frontiers in immunology · 2023Review
- Article
- Computational modelling of cell motility modes emerging from cell-matrix adhesion dynamics.PLoS computational biology · 2022Article
- Review
Corrections and comments
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Authors and funding
17 authors at 3 institutions in 1 country.
Alison Gaylo-MoynihanDavid H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA.
Hen PrizantDavid H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA.
Milan PopovićDavid H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA.
Ninoshka R J FernandesDavid H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA; Department of Biomedical Engineering, University of Rochester, Rochester, NY 14642, USA.
Christopher S AndersonDavid H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA.
Kevin K ChiouDepartment of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA.
Hannah BellDavid H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA.
Dillon C SchrockDavid H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA.
Justin SchumacherDepartment of Biomedical Engineering, University of Rochester, Rochester, NY 14642, USA.
Tara CapeceDavid H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA.
Brandon L WallingDavid H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA.
David J TophamDavid H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA.
Jim MillerDavid H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA.
Alan V SmrckaDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA.
Minsoo KimDavid H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA.
Angela HughsonDavid H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA.
Deborah J FowellDavid H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA. Electronic address: deborah_fowell@urmc.rochester.edu.
University of Rochester Medical Center · USUniversity of Pennsylvania · USUniversity of Rochester · US
Funding
Tissue regulation of T cell function - Reagents CoreP01AI102851 · NIAID · UNIVERSITY OF ROCHESTER · PI Iwijn De Vlaminck · 2014 to 2026
$26.0MThe T32 Predoctoral Training Program in Immunology (PTPI)T32AI007285 · NIAID · UNIVERSITY OF ROCHESTER · PI Scott Andrew Gerber, JACQUES Robert · 1986 to 2026
$7.6MUnderstanding and Manipulating Phospholipase C and G Protein beta gamma subunit Signaling NetworksR35GM127303 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alan V. Smrcka · 2018 to 2026
$4.8MRemodeling of Lymph Node-Derived Cytokine Responses at the Infected Tissue SiteR01AI072690 · NIAID · UNIVERSITY OF ROCHESTER · PI FOWELL, DEBORAH J · 2008 to 2020
$3.6MRemodeling of Lymph Node-Derived Cytokine Responses at the Infected Tissue SiteR37AI072690 · NIAID · CORNELL UNIVERSITY · PI Deborah J Fowell · 2023 to 2026
$1.9MTarget T Cell Modulation by CD4+CD25+ Regulatory T CellsR01AI070826 · NIAID · UNIVERSITY OF ROCHESTER · PI FOWELL, DEBORAH J · 2007 to 2010
$1.5MThe influence of inflammation on CD4 T cell interstitial migrationF30AI114036 · NIAID · UNIVERSITY OF ROCHESTER · PI GAYLO, ALISON E · 2014 to 2017
$188kRole of focal CXCL10 in shaping Th1 micro-positioning and function in inflamed skinF32AI138415 · NIAID · UNIVERSITY OF ROCHESTER · PI PRIZANT, HEN · 2018 to 2020
$142kNIAID NIH HHS F30 AI114036NIAID NIH HHS F32 AI138415NIAID NIH HHS P01 AI102851NIAID NIH HHS R01 AI070826NIAID NIH HHS R01 AI072690NIAID NIH HHS R37 AI072690NIAID NIH HHS T32 AI007285NIGMS NIH HHS R35 GM127303
Abstract
T-helper (Th) cell differentiation drives specialized gene programs that dictate effector T cell function at sites of infection. Here, we have shown Th cell differentiation also imposes discrete motility gene programs that shape Th1 and Th2 cell navigation of the inflamed dermis. Th1 cells scanned a smaller tissue area in a G protein-coupled receptor (GPCR) and chemokine-dependent fashion, while Th2 cells scanned a larger tissue area independent of GPCR signals. Differential chemokine reliance for interstitial migration was linked to STAT6 transcription-factor-dependent programming of integrin α
Indexed as
Adoptive TransferAnimalsCell DifferentiationCell MovementCells, CulturedCellular Reprogramming TechniquesChemokinesHumansInflammationIntegrin alphaVbeta3Lymphocyte ActivationMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutSTAT6 Transcription FactorChemokinesIntegrin alphaVbeta3STAT6 Transcription FactorchemokineGPCRinflammationintegrininterstitial motilityskinSTAT6Th1Th2Th differentiation
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