ArticleBMC complementary and alternative medicine2019
Water extract of Cnidii Rhizoma suppresses RANKL-induced osteoclastogenesis in RAW 264.7 cell by inhibiting NFATc1/c-Fos signaling and prevents ovariectomized bone loss in SD-rat.
Article in BMC complementary and alternative medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
- A Standard Herbal Formula, CGAC, Attenuates Bone Loss by Normalizing Low-Bone Turnover Stagnation in an Orchiectomy-Induced Mouse Model.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Genotoxicity and acute toxicity of Hyunburikyung-tang: assessing the safety of prescribing traditional Korean medicine for dysmenorrhea.BMC complementary medicine and therapies · 2025Article
- Effects ofInternational journal of molecular sciences · 2025Article
- Alkylphthalides with intracellular triglyceride metabolism-promoting activity from the rhizomes of Cnidium officinale Makino.Journal of natural medicines · 2024Article
- Effect ofMarine drugs · 2024Article
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- Effect of Ishophloroglucin A Isolated fromMarine drugs · 2023Article
- Response ofPlants (Basel, Switzerland) · 2022Article
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- Three New Phthalide Glycosides from the Rhizomes ofMolecules (Basel, Switzerland) · 2021Article
- Effects ofMolecular medicine reports · 2021Article
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- Downregulation of miR‑146a inhibits osteoporosis in the jaws of ovariectomized rats by regulating the Wnt/β‑catenin signaling pathway.International journal of molecular medicine · 2021Article
- Effects ofFrontiers in pharmacology · 2021Article
- [Risedronate inhibits rat bone marrow adipogenesis and reduces RANKL expression in adipocytes].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2019Article
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6 authors.
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Abstract
backgroundCnidii Rhizoma is the dried root stem of Cnidium officinale Makino. Cnidii Rhizoma (CR) has been used to treat menstrual irregularity, menstrual pain, and menopause in Korea. However, the effects and mechanisms of CR on RANKL-induced osteoclastogenesis pathway remain to be elucidated. In this study, we investigated the effects of CR on the inhibition of bone resorption of osteoclast and its mechanism RANK signaling pathway.
methodsThe anti-osteoclastogenesis of water extract of CR was measured using RAW 264.7 cell. Tartrate-resistant acid phosphatase (TRAP) assay, pit assay, reverse transcription polymerase chain reaction (RT-PCR) and western blot were performed. Moreover, the effects of CR were determined with an in vivo model using ovariectomized (OVX) rats.
resultsCR extract suppressed osteoclastogenesis, its activity and bone resorption activity through decreasing gene of osteoclast-related such as nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1), c-Fos, etc. Moreover, CR extract prevented the bone loss in OVX rats.
conclusionThese results show that CR has a positive effect on menopausal osteoporosis by suppressing osteoclastogenesis.
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