Evidence map›Paper›PMID 31399069›Full record

ArticleBMC neurology2019

Extensive immune reconstitution inflammatory syndrome in Fingolimod-associated PML: a case report with 7 Tesla MRI data.

Tim Sinnecker, Jeffrie Hadisurya, Tilman Schneider-Hohendorf, Nicholas Schwab, Karsten Wrede, Oliver Gembruch, Ralf Gold, Kerstin Hellwig, Sara Pilgram-Pastor, Ortwin Adams and 4 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in BMC neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 2 countries.

Tim SinneckerDepartment of Neurology, Universitätsspital, Basel, Switzerland.
Jeffrie HadisuryaDepartment of Neurology, Alfried Krupp von Bohlen und Halbach Hospital, Alfried-Krupp-Str. 21, 45117, Essen, Germany.
Tilman Schneider-HohendorfClinic of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany.
Nicholas SchwabClinic of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany.
Karsten WredeDepartment of Neurosurgery, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Oliver GembruchDepartment of Neurosurgery, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Ralf GoldDepartment of Neurology, St. Josef Hospital, Ruhr-University Bochum, Bochum, Germany.
Kerstin HellwigDepartment of Neurology, St. Josef Hospital, Ruhr-University Bochum, Bochum, Germany.
Sara Pilgram-PastorDepartment of Neuroradiology, Alfried Krupp Hospital, Essen, Germany.
Ortwin AdamsInstitute of Virology, Medical Faculty, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
Philipp AlbrechtDepartment of Neurology, Medical Faculty, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
Hans-Peter HartungDepartment of Neurology, Medical Faculty, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
Orhan AktasDepartment of Neurology, Medical Faculty, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
Markus KraemerDepartment of Neurology, Alfried Krupp von Bohlen und Halbach Hospital, Alfried-Krupp-Str. 21, 45117, Essen, Germany. markus.kraemer@krupp-krankenhaus.de.ORCID http://orcid.org/0000-0002-5667-3621
Heinrich Heine University Düsseldorf · DEErwin L. Hahn Institute for Magnetic Resonance Imaging · DESt. Josef-Hospital · DEUniversity Hospital Münster · DEAlfried Krupp Hospital · DEAlfried Krupp von Bohlen und Halbach Foundation · DEUniversity of Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProgressive multifocal leukoencephalopathy (PML) is a rare complication of patients treated with fingolimod. CASE PRESENTATION: Routine MRI eventually led to diagnosis of asymptomatic early PML that remained stable after discontinuation of fingolimod. As blood lymphocyte counts normalized, signs of immune reconstitution inflammatory syndrome (IRIS) and renewed MS activity developed. Both, advanced laboratory and ultrahigh field MRI findings elucidated differences between PML and MS.

conclusionsIn our case, early discontinuation of fingolimod yielded a good outcome, lymphocyte counts reflected immune system activity, and paraclinical findings helped to differentiate between PML-IRIS and MS.

Indexed as

AdultFingolimod HydrochlorideHumansImmune Reconstitution Inflammatory SyndromeImmunosuppressive AgentsLeukoencephalopathy, Progressive MultifocalMagnetic Resonance ImagingMaleMultiple Sclerosis, Relapsing-RemittingFingolimod HydrochlorideImmunosuppressive Agents7 tesla MRIFingolimodImmune reconstitution inflammatory syndromeMultiple sclerosisProgressive multifocal leucencephalopathy

Identifiers

PMID31399069
PMCPMC6688281
OpenAlexW2967120699

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.