ArticleBMC medical genetics2019
Shine & Lal index as a predictor for early detection of β-thalassemia carriers in a limited resource area in Bandung, Indonesia.
Article in BMC medical genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Digital Imaging of Peripheral Blood Smear With MC-80 as a Screening Tool for Thalassemia.Journal of clinical laboratory analysis · 2025Article
- Anaemia Profile and Inflammation Markers in Stunted Children Under Two Years in Indonesia.Children (Basel, Switzerland) · 2024Article
- Article
- Genetic Study for Identifying Beta Thalassemia Trait in Relatives of Children with Beta Thalassemia Major.Cureus · 2024Article
- Multi-criteria decision making to validate performance of RBC-based formulae to screenBMC medical informatics and decision making · 2024Article
- Extended family thalassemia screening as a feasible alternative method to be implemented in identifying carriers in West Java, Indonesia.Journal of community genetics · 2022Article
- Cell-free fetal DNA as a non-invasive method using pyrosequencing in detecting beta-globin gene mutation: A pilot study from area with limited facilities in Indonesia.Frontiers in pediatrics · 2022Article
- Prevalence of iron deficiency anemia and beta thalassemia carriers among relatives of beta thalassemia patients in Nile Delta region, Egypt: a multicenter study.The Journal of the Egyptian Public Health Association · 2021Article
- Knowledge Gaps in Understanding the Etiology of Anemia in Indonesian Adolescents.Food and nutrition bulletin · 2021Review
- Challenges in Thalassemia Carrier Detection in a Low Resource Setting Area of Eastern Indonesia: the Use of Erythrocyte Indices.Mediterranean journal of hematology and infectious diseases · 2021Article
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5 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThalassemia is the most common inherited disease in the world, involving α- or β-globin in red blood cells. Thalassemia cases rank fifth in the list of national catastrophic diseases in Indonesia; however, nationwide screening for thalassemia carriers is not yet mandatory. This study aimed to assess whether blood count metrics, such as the Shine & Lal index (SLI; MCV*MCV*MCH/100), might serve as a predictor to screen thalassemia carriers in a limited resource area where molecular methods are not readily available.
methodsDuring a family gathering of thalassemia patients, family members (n196) underwent a complete blood count test. Those with MCV < 80 fL and/or MCH < 27 pg and/or SLI < 1530 were further examined for Hb analysis. Only samples with HbA2 fraction > 4% or with a peak in the HbE fraction were sequenced to confirm β-globin gene mutations.
resultsOf 196 family members, 117 (59.6%) had low MCV and/or low MCH and/or low SLI. The HbE fraction (mean 24.06% ± 0.95, range 22.4-26.5) was found in 27 (13.7%) cases, and all had a mutation at codon (CD)26 (c.79G > A). The mean HbA
conclusionsThe Shine & Lal index is helpful in the early screening of β-thalassemia carriers, since this index confirms mutations at CD-26 (c.79G > A) and at IVS1nt5 (c.92 + 5 G > C), which are both common mutations in Bandung, Indonesia. Further DNA analysis is a topic of interest to map variants in globin genes and their distribution across populations.
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