ArticleJournal of ovarian research2019
Abnormal expression of HSP70 may contribute to PCOS pathology.
Article in Journal of ovarian research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- The effect of glutamine on Dehydroepiandrosterone-induced polycystic ovary syndrome rats.Journal of ovarian research · 2020Trial
- Inflammation and polyendocrine metabolic ovarian syndrome: utilizing proteomics to unravel this link in adolescents.Journal of the Endocrine Society · 2026Article
- Inflammatory response and immunological alteration in polycystic ovary syndrome: An integrative case-control study.Molecular biology reports · 2026Article
- An Exploratory Study of Heat Shock Protein Changes in Women with Unexplained Infertility.International journal of molecular sciences · 2026Article
- A matter of new life and cell death: programmed cell death in the mammalian ovary.Journal of biomedical science · 2024Review
- The Role of Heat Shock Proteins in the Pathogenesis of Polycystic Ovarian Syndrome: A Review of the Literature.International journal of molecular sciences · 2023Review
- Investigation of the effects of astaxanthin in experimental polycystic ovary syndrome (PCOS) in rats.Iranian journal of basic medical sciences · 2023Article
- Overexpression of miR-144-3p alleviates polycystic ovaries syndrome through targeting expression of HSP-70.Gene therapy · 2022Article
- Investigation of the mechanisms and experimental verification of Cuscuta-Salvia in the treatment of polycystic ovary syndrome (PCOS) via network pharmacology.Journal of ovarian research · 2022Article
- The abnormal level of HSP70 is related to Treg/Th17 imbalance in PCOS patients.Journal of ovarian research · 2021Article
- Serum Sex Hormone Binding Globulin Concentration as a Predictor of Ovarian Response During Controlled Ovarian Hyperstimulation.Frontiers in medicine · 2021Article
- Catechins from oolong tea improve uterine defects by inhibiting STAT3 signaling in polycystic ovary syndrome mice.Chinese medicine · 2020Article
- Understanding the Toxin Effects of β-Zearalenol and HT-2 on Bovine Granulosa Cells Using iTRAQ-Based Proteomics.Animals : an open access journal from MDPI · 2020Article
- Impaired heat shock protein 72 expression in women with polycystic ovary syndrome following a supervised exercise programme.Cell stress & chaperones · 2020Article
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4 authors at 2 institutions in 1 country.
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Abstract
backgroundThe mechanism of the pathological change of polycystic ovary syndrome (PCOS) is still unclear. Previous studies have shown that PCOS is a chronic nonspecific low-grade inflammatory condition, and that heat shock protein (HSP)70 has a potent anti-inflammatory property. So the aim of this study is to investigate the correlation between HSP70 and the hormones and inflammatory factors and to find out the role of HSP70 in the pathogenesis of PCOS.
methodsTwenty female Sprague-Dawley (SD) rats (aged 23 days and weighted 80-90 g) were randomly divided into two groups (n = 10 per group), PCOS group and control group. PCOS group were subcutaneously injected with 6 mg/100 g dehydro-epiandrosterone (DHEA) for 20 consecutive days, the control group were subcutaneously injected with a solvent of equivalent amount. All the samples were collected in the morning fasting state, 12 h after the last administration. Histological examinations of ovarian tissues were analyzed. Hormone levels and inflammatory factors levels were measured by enzyme-linked immunosorbent assay (ELISA) kits.
resultsSerum concentrations of testosterone (T) and luteinizing hormone (LH) were significantly higher in the PCOS group than the control group (P < 0.001), but the concentrations of estradiol (E
conclusionThe abnormal expression of HSP70 correlated with testosterone and inflammatory factors, which indicates that HSP70 may play an important role in PCOS pathology.
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