Evidence map›Paper›PMID 31398956›Full record

ArticleInternational journal of molecular sciences2019

Structural and Functional Properties of the Capsid Protein of Dengue and Related

André F Faustino, Ana S Martins, Nina Karguth, Vanessa Artilheiro, Francisco J Enguita, Joana C Ricardo, Nuno C Santos, Ivo C Martins

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Zika virus capsid protein closed structure modulates binding to host lipid systems.Protein science : a publication of the Protein Society · 2024
    Article
  7. Review
  8. Vital for Viruses: Intrinsically Disordered Proteins.Journal of molecular biology · 2023
    Review
  9. Dengue Virus Capsid Protein Facilitates Genome Compaction and Packaging.International journal of molecular sciences · 2023
    Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Macromolecular Interactions of Disordered Proteins.International journal of molecular sciences · 2020
    Article
  17. Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

André F FaustinoInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisbon, Portugal.
Ana S MartinsInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisbon, Portugal.
Nina KarguthInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisbon, Portugal.
Vanessa ArtilheiroInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisbon, Portugal.
Francisco J EnguitaInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisbon, Portugal.
Joana C RicardoCentro de Química-Física Molecular, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisbon, Portugal.
Nuno C SantosInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisbon, Portugal. nsantos@fm.ul.pt.
Ivo C MartinsInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisbon, Portugal. ivomartins@fm.ul.pt.
University of Lisbon · PT

Funding

Effects of Public Information in Cancer (EPIC Center)P50CA095856 · NCI · UNIVERSITY OF PENNSYLVANIA · PI HORNIK, ROBERT C. · 2003 to 2007
$10.1M
Training / Career DevelopmentP20CA095856 · NCI · UNIVERSITY OF PENNSYLVANIA · PI HORNIK, ROBERT C. · 2008 to 2012
$8.7M
Development and testing of a silibin-containing sunscreenR41CA117013 · NCI · PROTECHSURE SCIENTIFIC, INC. · PI GLODE, L MICHAEL · 2007 to 2007
$108k
THE IGF SYSTEM AS A TREATMENT TARGET IN BREAST CANCERK04CA001670 · NCI · UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT · PI YEE, DOUGLAS · 1992 to 1996
–
Fundação Calouste Gulbenkian Project Science Frontiers Research Prize 2010Fundação para a Ciência e a Tecnologia Fellowship PD/BD/113698/2015Fundação para a Ciência e a Tecnologia Fellowship SFRH/BD/77609/2011Fundação para a Ciência e a Tecnologia Fellowship SFRH/BD/95856/2013Fundação para a Ciência e a Tecnologia Program Concurso de Estímulo ao Emprego Científico (CEECIND/01670/2017)Fundação para a Ciência e a Tecnologia Program Investigador FCT (IF/00772/2013)Fundação para a Ciência e a Tecnologia Project PTDC/SAU-ENB/117013/2010Fundação para a Ciência e a Tecnologia Project UID/BIM/50005/2019, Fundos do Orçamento do Estado
6 · The paper itself

Abstract

Dengue, West Nile and Zika, closely related viruses of the Flaviviridae family, are an increasing global threat, due to the expansion of their mosquito vectors. They present a very similar viral particle with an outer lipid bilayer containing two viral proteins and, within it, the nucleocapsid core. This core is composed by the viral RNA complexed with multiple copies of the capsid protein, a crucial structural protein that mediates not only viral assembly, but also encapsidation, by interacting with host lipid systems. The capsid is a homodimeric protein that contains a disordered N-terminal region, an intermediate flexible fold section and a very stable conserved fold region. Since a better understanding of its structure can give light into its biological activity, here, first, we compared and analyzed relevant mosquito-borne

Indexed as

Dengue VirusFlavivirusAmino Acid SequenceAnimalsCapsid ProteinsConserved SequenceEvolution, MolecularHumansHydrophobic and Hydrophilic InteractionsPhylogenyProtein ConformationProtein StabilityStructure-Activity RelationshipCapsid Proteinscapsid protein (C protein)circular dichroismDengue virus (DENV)Flavivirusintrinsically disordered protein (IDP)protein–host lipid systems interactionprotein–RNA interactionstime-resolved fluorescence anisotropy

Identifiers

PMID31398956
PMCPMC6720645
OpenAlexW2966796379

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.