ArticleInternational journal of molecular sciences2019
Versatile Biomaterial Platform Enriched with Graphene Oxide and Carbon Nanotubes for Multiple Tissue Engineering Applications.
Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- Advanced Nanobiocomposite Hydrogels Incorporating Organofunctionalized LDH for Soft Tissue Engineering Applications.Polymers · 2025Article
- Reinforcing Restorative Dentistry: The Dual Role of Carbon Nanotubes in Material Enhancement and Therapy.International journal of dentistry · 2025Review
- Advances in graphene-based 2D materials for tendon, nerve, bone/cartilage regeneration and biomedicine.iScience · 2024Review
- Double-Reinforced Fish Gelatin Composite Scaffolds for Osteochondral Substitutes.Materials (Basel, Switzerland) · 2023Article
- Graphene Oxide Functionalized Gelatin Methacryloyl Microgel for Enhanced Biomimetic Mineralization and in situ Bone Repair.International journal of nanomedicine · 2023Article
- A CS-based composite scaffold with excellent photothermal effect and its application in full-thickness skin wound healing.Regenerative biomaterials · 2023Article
- Graphene and graphene-based materials in axonal repair of spinal cord injury.Neural regeneration research · 2022Review
- Translating Material Science into Bone Regenerative Medicine Applications: State-of-The Art Methods and Protocols.International journal of molecular sciences · 2022Review
- Suitability of Chitosan Scaffolds with Carbon Nanotubes for Bone Defects Treated with Photobiomodulation.International journal of molecular sciences · 2022Article
- Silk ProteinsEnriched Nanocomposite Hydrogels Based on Modified MMT Clay and Poly(2-hydroxyethyl methacrylate-co-2-acrylamido-2-methylpropane Sulfonic Acid) Display Favorable Properties for Soft Tissue Engineering.Nanomaterials (Basel, Switzerland) · 2022Article
- Graphene-Oxide Porous Biopolymer Hybrids Enhance In Vitro Osteogenic Differentiation and Promote Ectopic Osteogenesis In Vivo.International journal of molecular sciences · 2022Article
- Modelling of Stem Cells Microenvironment Using Carbon-Based Scaffold for Tissue Engineering Application-A Review.Polymers · 2021Review
- Computed Tomography as a Characterization Tool for Engineered Scaffolds with Biomedical Applications.Materials (Basel, Switzerland) · 2021Review
- Review
- Cellulose Composites with Graphene for Tissue Engineering Applications.Materials (Basel, Switzerland) · 2020Review
- Release of the Non-Steroidal Anti-Inflammatory Drug Flufenamic Acid by Multiparticulate Delivery Systems Promotes Adipogenic Differentiation of Adipose-Derived Stem Cells.Materials (Basel, Switzerland) · 2020Article
- Graphene Oxide Enhances Chitosan-Based 3D Scaffold Properties for Bone Tissue Engineering.International journal of molecular sciences · 2019Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Carbon-based nanomaterials, such as graphene oxide (GO) or carbon nanotubes (CNTs) are currently used in various medical applications due to their positive influence on biocompatibility, adhesion, proliferation, and differentiation, as well as their contribution to modulating cell behavior in response to nanomaterial substrates. In this context, in this study, novel flexible membranes based on cellulose acetate (CA) enriched with CNT and GO in different percentages were tested for their versatility to be used as substrates for soft or hard tissue engineering (TE), namely, for their ability to support human adipose-derived stem cells (hASCs) adhesion during adipogenic or osteogenic differentiation. For this purpose, differentiation markers were assessed both at gene and protein levels, while histological staining was performed to show the evolution of the processes in response to CA-CNT-GO substrates. Micro-CT analysis indicated porous morphologies with open and interconnected voids. A slightly lower total porosity was obtained for the samples filled with the highest amount of GO and CNTs, but thicker walls, larger and more uniform pores were obtained, providing beneficial effects on cell behavior and increased mechanical stability. The addition of 1 wt% GO and CNT to the biocomposites enhanced hASCs adhesion and cytoskeleton formation. The evolution of both adipogenic and osteogenic differentiation processes was found to be augmented proportionally to the GO-CNT concentration. In conclusion, CA-CNT-GO biomaterials displayed good properties and versatility as platforms for cell differentiation with potential as future implantable materials in TE applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.