Evidence map›Paper›PMID 31398617›Full record

ArticleMedical image analysis2019

Surface-constrained volumetric registration for the early developing brain.

Sahar Ahmad, Zhengwang Wu, Gang Li, Li Wang, Weili Lin, Pew-Thian Yap, Dinggang Shen

Abstract read
In one paragraph

Article in Medical image analysis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Unified Brain Surface and Volume Registration.... International Conference on Learning Representations · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Surface-Volume Consistent Construction of Longitudinal Atlases for the Early Developing Brain.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2019
    Article
  7. Surface-Guided Image Fusion for Preserving Cortical Details in Human Brain Templates.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sahar AhmadDepartment of Radiology and Biomedical Research Imaging Center (BRIC), University of North Carolina, Chapel Hill, United States.
Zhengwang WuDepartment of Radiology and Biomedical Research Imaging Center (BRIC), University of North Carolina, Chapel Hill, United States.
Gang LiDepartment of Radiology and Biomedical Research Imaging Center (BRIC), University of North Carolina, Chapel Hill, United States.
Li WangDepartment of Radiology and Biomedical Research Imaging Center (BRIC), University of North Carolina, Chapel Hill, United States.
Weili LinDepartment of Radiology and Biomedical Research Imaging Center (BRIC), University of North Carolina, Chapel Hill, United States.
Pew-Thian YapDepartment of Radiology and Biomedical Research Imaging Center (BRIC), University of North Carolina, Chapel Hill, United States. Electronic address: ptyap@med.unc.edu.
Dinggang ShenDepartment of Radiology and Biomedical Research Imaging Center (BRIC), University of North Carolina, Chapel Hill, United States; Department of Brain and Cognitive Engineering, Korea University, Seoul 02841, Republic of Korea. Electronic address: dgshen@med.unc.edu.

Funding

Longitudinal Mapping of Human Brain Development in the First Years of LifeR01EB008374 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YAP, PEW-THIAN · 2009 to 2024
$5.1M
Analyzing Large-Scale Neuroimaging Data in Alzheimer's DiseaseRF1AG053867 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YAP, PEW-THIAN · 2016 to 2016
$2.5M
Continued Development of Infant Brain Analysis ToolsR01MH117943 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, GANG, WANG, LI · 2018 to 2022
$2.3M
4D Cortical Surface Analysis Tools for Study of Early Brain Development in Typical and High-risk InfantsK01MH107815 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, GANG · 2015 to 2018
$559k
NIA NIH HHS RF1 AG053867NIBIB NIH HHS R01 EB008374NIMH NIH HHS K01 MH107815NIMH NIH HHS R01 MH117943
6 · The paper itself

Abstract

The T1-weighted and T2-weighted MRI contrasts of the infant brain evolve drastically during the first year of life. This poses significant challenges to inter- and intra-subject registration, which is key to subsequent statistical analyses. Existing registration methods that do not consider temporal contrast changes are ineffective for infant brain MRI data. To address this problem, we present in this paper a method for deformable registration of infant brain MRI. The key advantage of our method is threefold: (i) To deal with appearance changes, registration is performed based on segmented tissue maps instead of image intensity. Segmentation is performed by using an infant-centric algorithm previously developed by our group. (ii) Registration is carried out with respect to both cortical surfaces and volumetric tissue maps, thus allowing precise alignment of both cortical and subcortical structures. (iii) A dynamic elasticity model is utilized to allow large non-linear deformation. Experimental results in comparison with well-established registration methods indicate that our method yields superior accuracy in both cortical and subcortical alignment.

Indexed as

AlgorithmsBrainBrain MappingDatasets as TopicFemaleHumansImage EnhancementImage Processing, Computer-AssistedInfantMagnetic Resonance ImagingMalePattern Recognition, AutomatedInfant magnetic resonance imagingJoint cortical surface and volumetric registration

Identifiers

PMID31398617
PMCPMC6815721

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.