Evidence map›Paper›PMID 31398537›Full record

ArticleRespiratory physiology & neurobiology2019

The voltage-gated sodium channel Na

M Brozmanova, S Svajdova, N Pavelkova, Y Muroi, B J Undem, M Kollarik

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory physiology & neurobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Review
  3. Prostaglandin ERespiratory research · 2021
    Article
  4. Article
  5. Antitussive effects of NaEuropean journal of pharmacology · 2021
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

M BrozmanovaDepartment of Pathophysiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia; Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia.
S SvajdovaDepartment of Pathophysiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia; Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia.
N PavelkovaDepartment of Pathophysiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia; Department of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States.
Y MuroiDepartment of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.
B J UndemDepartment of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.
M KollarikDepartment of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States. Electronic address: kollarik@health.usf.edu.
Comenius University Bratislava · SKJohns Hopkins Medicine · USUniversity of South Florida · US

Funding

Control of Airway Sensory Nerve Function by Voltage-Gated Sodium Channel SubtypesR01HL122228 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI UNDEM, BRADLEY JOEL · 2014 to 2020
$3.2M
Cholinergic mechanisms involved in transduction of airway defensive reflexesR01HL141251 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CANNING, BRENDAN J · 2019 to 2021
$1.6M
Ionic and Structural Mechanisms for Sensory Neuromodulation of the EsophagusU01DK116311 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI TAYLOR-CLARK, THOMAS EDWARD · 2017 to 2019
$786k
NHLBI NIH HHS R01 HL122228NHLBI NIH HHS R01 HL141251NIDDK NIH HHS U01 DK116311
6 · The paper itself

Abstract

Cough in respiratory diseases is attributed to the activation of airway C-fibers by inflammation. Inflammatory mediators can act on multiple receptors expressed in airway C-fibers, nonetheless, the action potential initiation in C-fibers depends on a limited number of voltage-gated sodium channel (Na

Indexed as

Action PotentialsAdministration, InhalationAniline CompoundsAnimalsAntitussive AgentsBronchiCoughDose-Response Relationship, DrugFuransGuinea PigsInjections, IntraperitonealLungMaleNAV1.8 Voltage-Gated Sodium ChannelNerve Fibers, UnmyelinatedPresynaptic TerminalsA 803467Aniline CompoundsAntitussive AgentsFuransNAV1.8 Voltage-Gated Sodium ChannelSodium Channel BlockersBronchopulmonary C-fibersCoughNaV1.8Vagus nerveVoltage-gated sodium channels

Identifiers

PMID31398537
PMCPMC12884508
OpenAlexW2966360682

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.