Evidence map›Paper›PMID 31398491›Full record

ArticleCellular and molecular gastroenterology and hepatology2019

TRPV6 and Ca

Megan R Beggs, Justin J Lee, Kai Busch, Ahsan Raza, Henrik Dimke, Petra Weissgerber, Jutta Engel, Veit Flockerzi, R Todd Alexander

Open access · goldAbstract read
In one paragraph

Article in Cellular and molecular gastroenterology and hepatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Monosodium glutamate-mediated CaPhysiological reports · 2026
    Article
  3. TRPV6 channel function is involved in endometrial epithelial cell CaCellular and molecular life sciences : CMLS · 2025
    Article
  4. Article
  5. Biology of calcium homeostasis regulation in intestine and kidney.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. CaFrontiers in pharmacology · 2022
    Article
  13. Review
  14. Claudin-2 and claudin-12 form independent, complementary pores required to maintain calcium homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Dynamics of Intestinal Calcium Absorption in Neonates.Cellular and molecular gastroenterology and hepatology · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Megan R BeggsDepartment of Physiology, University of Alberta, Edmonton, Alberta, Canada; The Women's & Children's Health Research Institute, Edmonton, Alberta, Canada.
Justin J LeeDepartment of Physiology, University of Alberta, Edmonton, Alberta, Canada; The Women's & Children's Health Research Institute, Edmonton, Alberta, Canada.
Kai BuschExperimentelle und Klinische Pharmakologie und Toxikologie, Saarland University, Homburg, Germany.
Ahsan RazaExperimentelle und Klinische Pharmakologie und Toxikologie, Saarland University, Homburg, Germany.
Henrik DimkeDepartment of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Petra WeissgerberExperimentelle und Klinische Pharmakologie und Toxikologie, Saarland University, Homburg, Germany.
Jutta EngelDepartment of Biophysics, Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, School of Medicine, Homburg, Germany.
Veit FlockerziExperimentelle und Klinische Pharmakologie und Toxikologie, Saarland University, Homburg, Germany.
R Todd AlexanderDepartment of Physiology, University of Alberta, Edmonton, Alberta, Canada; The Women's & Children's Health Research Institute, Edmonton, Alberta, Canada; Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada. Electronic address: todd2@ualberta.ca.
Saarland University · DEUniversity of Alberta · CAUniversity of Southern Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND &

aimsIntestinal Ca

methodsExpression of small intestinal and renal calcium transport genes was assessed by using quantitative polymerase chain reaction. Net calcium flux across small intestinal segments was measured in Ussing chambers, including after pharmacologic inhibition or genetic manipulation of TRPV6 or Ca

resultsNet TRPV6-mediated Ca

conclusionsWe have detailed novel pathways contributing to transcellular Ca

Indexed as

AnimalsCalcification, PhysiologicCalciumCalcium ChannelsCalcium Channels, L-TypeCalcium, DietaryFemaleIntestinal AbsorptionIntestinal MucosaIntestine, SmallIon TransportMaleMiceMice, Inbred StrainsMice, KnockoutTranscriptomeCacna1d protein, mouseCalciumCalcium ChannelsCalcium Channels, L-TypeCalcium, DietaryTrpv6 protein, mouseTRPV Cation ChannelsBoneCalcium ChannelDevelopmentPediatric

Identifiers

PMID31398491
PMCPMC6889763
OpenAlexW2964780775

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.