ArticleThe Journal of experimental medicine1988
Interaction and sequence diversity among T15 VH genes in CBA/J mice.
Article in The Journal of experimental medicine, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 20 citations in OpenAlex.
- Integrating computationally assembled mouse transcript sequences with the Mouse Genome Informatics (MGI) database.Genome biology · 2003Article
- VH gene family expression in mice with the xid defect.The Journal of experimental medicine · 1991Article
- Characterization of somatically mutated S107 VH11-encoded anti-DNA autoantibodies derived from autoimmune (NZB x NZW)F1 mice.The Journal of experimental medicine · 1991Article
- A novel class of anti-DNA antibodies identified in BALB/c mice.The Journal of experimental medicine · 1991Article
- Two closely related kappa variable region pseudogenes pose an evolutionary paradox.Immunogenetics · 1991Article
- Analysis of a novel VHS107 haplotype in CLA-2 and WSA mice. Evidence for gene conversion among IgVH genes in outbred populations.The Journal of experimental medicine · 1989Article
- 'Allelic' forms of immunoglobulin V genes in different strains of mice.The EMBO journal · 1989Article
- Mapping of antibody specificities to VH gene families.Immunogenetics · 1989Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Nucleotide sequences of the four genes composing the T15 heavy chain variable region (VH) family of the CBA/J mouse have been determined. Comparison of these sequences with their published BALB/c and C57BL/10 homologues reveals that nucleotide differences found between given alleles of two strains, i.e., CBA/J and BALB/c, are observed in other family members of the same strain. We suggest that these patterns of sequence variation are most readily explained by gene interaction (conversion). Additionally, the sequence of a CBA/J hybridoma, 6G6, proposed to have been generated by gene conversion, is directly encoded by the CBA/J V11 gene indicating that the putative conversion has occurred meiotically in the germline. These results are consistent with the premise that gene correction is occurring frequently among members of this family and that such processes may contribute significantly to the evolution of Ig variable region genes even in the relatively short time frame of inbred strain derivation.
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