Evidence map›Paper›PMID 31398053›Full record

ArticleMolecular pharmaceutics2019

Development of MicroRNA-146a-Enriched Stem Cell Secretome for Wound-Healing Applications.

Renae Waters, Siddharth Subham, Settimio Pacelli, Saman Modaresi, Aparna R Chakravarti, Arghya Paul

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmaceutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Integrative Approaches to Treating Cellular Senescence in Kidney Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  4. Advances in the Role of Stem Cell-Derived Exosomes in Diabetic Foot Wound Healing.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Renae WatersBioIntel Research Laboratory, Department of Chemical and Petroleum Engineering, School of Engineering , University of Kansas , Lawrence , Kansas 66045 , United States.
Siddharth SubhamBioIntel Research Laboratory, Department of Chemical and Petroleum Engineering, School of Engineering , University of Kansas , Lawrence , Kansas 66045 , United States.
Settimio PacelliBioIntel Research Laboratory, Department of Chemical and Petroleum Engineering, School of Engineering , University of Kansas , Lawrence , Kansas 66045 , United States.ORCID 0000-0002-4879-3615
Saman ModaresiBioIntel Research Laboratory, Department of Chemical and Petroleum Engineering, School of Engineering , University of Kansas , Lawrence , Kansas 66045 , United States.
Aparna R ChakravartiBioIntel Research Laboratory, Department of Chemical and Petroleum Engineering, School of Engineering , University of Kansas , Lawrence , Kansas 66045 , United States.
Arghya PaulBioIntel Research Laboratory, Department of Chemical and Petroleum Engineering, School of Engineering , University of Kansas , Lawrence , Kansas 66045 , United States.ORCID 0000-0003-4788-0378
University of Kansas · US

Funding

Understanding the mechanobiology of stem cells in a microengineered 3D cardiac tissue environment with cardiomyopathyP20GM103638 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI HOLMSTROM, ERIK D · 2012 to 2021
$22.1M
PHARMACEUTICAL ASPECTS OF BIOTECHNOLOGY TRAININGT32GM008359 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI SIAHAAN, TERUNA J., VOLKIN, DAVID · 1989 to 2018
$5.0M
NIGMS NIH HHS P20 GM103638NIGMS NIH HHS T32 GM008359
6 · The paper itself

Abstract

Secretome-based therapies have the potential to become the next generation of viable therapeutic wound repair treatments. However, precise strategies aimed to refine and control the secretome composition are necessary to enhance its therapeutic efficacy and facilitate clinical translation. In this study, we aim to accomplish this by transfecting human adipose-derived stem cells (hASCs) with microRNA-146a, which is a potent regulator of angiogenesis and inflammation. The secretome composition obtained from the transfected hASCs (secretome

Indexed as

Neovascularization, PhysiologicWound HealingAdipose TissueCell MovementCell ProliferationCells, CulturedHumansHuman Umbilical Vein Endothelial CellsInterleukin-1betaMicroRNAsStem CellsIL1B protein, humanInterleukin-1betaMicroRNAsMIRN146 microRNA, humanangiogenesisanti-inflammatory agentsextracellular vesiclesmicroRNAsecretome

Identifiers

PMID31398053
PMCPMC7260687
OpenAlexW2967610984

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.