ReviewHuman brain mapping2019
Stress and the brain: Perceived stress mediates the impact of the superior frontal gyrus spontaneous activity on depressive symptoms in late adolescence.
Review in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed, 3 syntheses or guidelines pooled it, 130 citations in OpenAlex.
- Extraversion and the resting brain: a coordinate-based meta-analysis of resting-state functional brain imaging studies.Brain structure & function · 2025Pooled it
- Aberrant resting-state brain activity in Huntington's disease: A voxel-based meta-analysis.Frontiers in neurology · 2023Pooled it
- Hyperconnectivity between the posterior cingulate and middle frontal and temporal gyrus in depression: Based on functional connectivity meta-analyses.Brain imaging and behavior · 2022Pooled it
- Effects of a Digital Mental Health Intervention on Perceived Stress and Rumination in Adolescents Aged 13 to 17 Years: Randomized Controlled Trial.Journal of medical Internet research · 2024Trial
- Conflict, mental health, and labor productivity: evidence from hired farm workers in Myanmar.BMC global and public health · 2026Article
- Shared subcortical-default mode morphological dysconnectivity in adolescent bipolar disorder, major depressive disorder and schizophrenia.Communications biology · 2026Article
- Investigating the impact of stressful life events on neuroanatomy across adolescence.bioRxiv : the preprint server for biology · 2026Article
- Multimodal MRI and machine learning for identifying depression in cerebral small vessel disease: a multicenter study.BMC medical imaging · 2026Article
- The relationship between perceived stress, psychological resilience, and depressive symptoms in college students, and the moderating role of gender.Scientific reports · 2026Article
- MASSAG model: Towards an integrative neuroscience framework linking emotional trauma, pain, and mechanisms of force-based manipulations.Neuroscience and biobehavioral reviews · 2026Review
- Perceived stress mediates the association between orbitofrontal cortex grey matter volume and depressive symptoms in older women.Scientific reports · 2025Article
- The relationship between screen time and anxiety/depression symptoms in preschool children with autism spectrum disorder: the mediating role of cortical volume.BMC pediatrics · 2025Observational
- Hidden Rhythms of a Developing Brain: Multimetric rs-fMRI Insights Into Typical Youth Maturation.Human brain mapping · 2025Article
- The Mediating Role of Sexual Mindfulness on the Relationship Between Black Women's Psychological and Sexual Functioning.Mindfulness · 2025Article
- Altered spontaneous brain activity in children with deprivation amblyopia: a resting-state functional magnetic resonance imaging study.European journal of medical research · 2025Article
- Causal Central Network Remodeling in Diabetic Neuropathy: An Integrated MR-fMRI Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Unveiling Frequency-Specific Microstate Correlates of Anxiety and Depression Symptoms.Brain topography · 2024Article
- Brain structural and functional abnormalities in affective network are associated with anxious depression.BMC psychiatry · 2024Article
- Web-Based Mindfulness-Based Cognitive Therapy for Adults With a History of Depression: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2024Article
- Neural Markers of Emotion Reactivity and Regulation Before and After a Targeted Social Rejection: Differences Among Girls With and Without Suicidal Ideation and Behavior Histories.Biological psychiatry · 2024Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Identifying factors for the prediction of depression is a long-standing research topic in psychiatry and psychology. Perceived stress, which reflects the tendency to appraise one's life situations as stressful and overwhelming, has emerged as a stable predictor for depressive symptoms. However, the neurobiological bases of perceived stress and how perceived stress influences depressive symptoms in the healthy brain remain largely unknown. Here, we investigated these issues in 217 healthy adolescents by estimating the fractional amplitude of low-frequency fluctuations (fALFFs) via resting-state functional magnetic resonance imaging. A whole-brain correlation analysis showed that higher levels of perceived stress were associated with greater fALFF in the left superior frontal gyrus (SFG), which is a core brain region for cognitive control and emotion regulation-related processes. Mediation analysis further indicated that perceived stress mediated the link between the fALFF in the left SFG and depressive symptoms. Importantly, our results remained significant even when excluding the influences of head motion, anxiety, SFG gray matter structure, and school environment. Altogether, our findings suggested that the fALFF in the left SFG is a neurofunctional marker of perceived stress in adolescents and revealed a potential indirect effect of perceived stress on the association between the SFG spontaneous activity and depressive symptoms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.