Evidence map›Paper›PMID 31397718›Full record

Trial reportAIDS (London, England)2019

Maternal HIV does not affect resiliency among uninfected/HIV exposed South African children from birth to 5 years of age.

Mary Jane Rotheram-Borus, Joan Christodoulou, Panteha Hayati Rezvan, W Scott Comulada, Sarah Gordon, Sarah Skeen, Jackie Stewart, Ellen Almirol, Mark Tomlinson

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in AIDS (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00996528 (Neighborhood Alcohol & HIV Prevention in South African Townships), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00996528 phase3unknown statusnot on this map

Neighborhood Alcohol & HIV Prevention in South African Townships (Philani)

TypeinterventionalSponsorUniversity of California, Los AngelesRan2007 to 2025Enrolled1,239ConditionsFetal Alcohol Syndrome, HIV, Nutrition DisordersArmsPhilani Intervention Program
3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. The Intergenerational Impact of a Slow Pandemic: HIV and Children.New directions for child and adolescent development · 2020
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mary Jane Rotheram-BorusDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute, University of California, Los Angeles, California, USA.
Joan ChristodoulouDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute, University of California, Los Angeles, California, USA.
Panteha Hayati RezvanDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute, University of California, Los Angeles, California, USA.
W Scott ComuladaDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute, University of California, Los Angeles, California, USA.
Sarah GordonDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute, University of California, Los Angeles, California, USA.
Sarah SkeenDepartment of Psychology, Stellenbosch University, Stellenbosch, South Africa.
Jackie StewartDepartment of Psychology, Stellenbosch University, Stellenbosch, South Africa.
Ellen AlmirolDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute, University of California, Los Angeles, California, USA.
Mark TomlinsonDepartment of Psychology, Stellenbosch University, Stellenbosch, South Africa.

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
UCLA Rapid, Relevant, Rigorous Implementation Science HubP30MH058107 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RAPHAEL J LANDOVITZ · 1997 to 2026
$53.5M
Virology CoreP30AI028697 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANTON, PETER A · 1991 to 2018
$39.9M
Neighborhood Alcohol & HIV Prevention in South African TownshipsR01AA017104 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROTHERAM-BORUS, MARY JANE · 2007 to 2011
$3.8M
Post-doctoral HIV Research Training Program for HIV Combination PreventionT32MH109205 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROTHERAM-BORUS, MARY JANE · 2016 to 2020
$2.3M
NCATS NIH HHS UL1 TR001881NIAAA NIH HHS R01 AA017104NIAID NIH HHS P30 AI028697NIMH NIH HHS P30 MH058107NIMH NIH HHS T32 MH109205
6 · The paper itself

Abstract

objectiveExamine resiliency among a South African population cohort of children of mothers living with HIV (MLH) and mothers without HIV (MWOH) in low-income townships over the first 5 years of life.

designA cluster randomized controlled intervention trial evaluating child resiliency and the effects of home visiting in township neighborhoods from pregnancy through 5 years postbirth.

methodsThe population of pregnant women in 24 matched neighborhoods were recruited and randomized by neighborhood to a standard care condition (n = 594) or a paraprofessional home visiting intervention condition (n = 644). Mothers and children were assessed at 2 weeks, 6, 18, 36, and 60 months postbirth (92-84% follow-up; 10.2% mortality). Resilient children were identified based on consistently meeting global standards for growth, cognitive functioning, and behavior. Maternal HIV status (n = 354 MLH; n = 723 mothers without HIV MWOH), intervention condition, maternal risks, caretaking, sociodemographic characteristics, and neighborhood were examined as predictors of child resiliency over time using analysis of variance, chi-square analyses, and Fisher's exact tests, where appropriate.

resultsNone of HIV-seropositive children (n = 17) were resilient; 19% of 345 HIV-exposed but uninfected children of MLH were resilient, a rate very similar to the 16% among MWOH. Resiliency was significantly associated with lower income, food security, not having a live-in partner, and the absence of maternal risk (i.e., not being depressed, using alcohol, or being a victim of intimate partner violence). Being randomized to a home visiting intervention, maternal breastfeeding for at least 3 months and attending a preschool crèche were also unrelated to resiliency. Although matched pairs of neighborhoods had similar rates of resilient children, resiliency varied significantly by neighborhood with rates ranging from 9.5 to 27%.

conclusionWe set a new standard to define resiliency, as consistently recommended by theoreticians. Although seropositive children are not resilient, uninfected children of MLH are as resilient as their peers of MWOH. Typical protective factors (e.g., home visiting, breastfeeding, preschool) were unrelated to resiliency over the first 5 years of life.

trial registrationClinicalTrials.gov registration #NCT00996528.

Indexed as

Adaptation, PsychologicalChild HealthAdultBreast FeedingChild, PreschoolDepressionFamily CharacteristicsFemaleHIV InfectionsHouse CallsHumansInfantInfant, NewbornInfectious Disease Transmission, VerticalMothersPostnatal Care

Identifiers

PMID31397718
PMCPMC6870979

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.