Evidence map›Paper›PMID 31397631›Full record

ArticlemAbs

Characterization of novel anti-IL-26 neutralizing monoclonal antibodies for the treatment of inflammatory diseases including psoriasis.

Ryo Hatano, Takumi Itoh, Haruna Otsuka, Sayo Okamoto, Eriko Komiya, Satoshi Iwata, Thomas M Aune, Nam H Dang, Kyoko Kuwahara-Arai, Kei Ohnuma and 1 more

Open access · goldAbstract read
In one paragraph

Article in mAbs. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Multifaceted Roles of IL-26 in Physiological and Pathological Conditions.International journal of molecular sciences · 2025
    Review
  3. Article
  4. Review
  5. Article
  6. The Immunology of Psoriasis-Current Concepts in Pathogenesis.Clinical reviews in allergy & immunology · 2024
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Molecular and Cellular Mechanisms of Itch in Psoriasis.International journal of molecular sciences · 2020
    Review
  12. The role of Th17 cells in psoriasis.Immunologic research · 2020
    Review
  13. Single-cell atlas of colonic CD8Nature medicine · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Ryo HatanoDepartment of Therapy Development and Innovation for Immune Disorders and Cancers, Graduate School of Medicine, Juntendo University , Tokyo , Japan.
Takumi ItohDepartment of Therapy Development and Innovation for Immune Disorders and Cancers, Graduate School of Medicine, Juntendo University , Tokyo , Japan.ORCID 0000-0002-6535-1042
Haruna OtsukaDepartment of Therapy Development and Innovation for Immune Disorders and Cancers, Graduate School of Medicine, Juntendo University , Tokyo , Japan.ORCID 0000-0001-9346-2658
Sayo OkamotoDepartment of Therapy Development and Innovation for Immune Disorders and Cancers, Graduate School of Medicine, Juntendo University , Tokyo , Japan.ORCID 0000-0002-1831-6770
Eriko KomiyaDepartment of Therapy Development and Innovation for Immune Disorders and Cancers, Graduate School of Medicine, Juntendo University , Tokyo , Japan.
Satoshi IwataDepartment of Therapy Development and Innovation for Immune Disorders and Cancers, Graduate School of Medicine, Juntendo University , Tokyo , Japan.ORCID 0000-0002-9160-4461
Thomas M AuneDepartment of Medicine, Vanderbilt University School of Medicine, Vanderbilt University Medical Center , Nashville , TN , USA.ORCID 0000-0002-4968-4306
Nam H DangDivision of Hematology/Oncology, University of Florida , Gainesville , FL , USA.
Kyoko Kuwahara-AraiDepartment of Microbiology, Juntendo University School of Medicine , Tokyo , Japan.
Kei OhnumaDepartment of Therapy Development and Innovation for Immune Disorders and Cancers, Graduate School of Medicine, Juntendo University , Tokyo , Japan.
Chikao MorimotoDepartment of Therapy Development and Innovation for Immune Disorders and Cancers, Graduate School of Medicine, Juntendo University , Tokyo , Japan.ORCID 0000-0002-3140-3596
Juntendo University · JPUniversity of Florida · USVanderbilt University Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interleukin (IL)-26, known as a Th17 cytokine, acts on various cell types and has multiple biological functions. Although its precise role still remains to be elucidated, IL-26 is suggested to be associated with the pathology of diverse chronic inflammatory diseases such as psoriasis, inflammatory bowel diseases and rheumatoid arthritis. To develop novel neutralizing anti-human IL-26 monoclonal antibodies (mAbs) for therapeutic use in the clinical setting, we immunized mice with human IL-26 protein. Hybridomas producing anti-IL-26 mAbs were screened for various

Indexed as

Antibodies, Monoclonal, Murine-DerivedAntibodies, NeutralizingPsoriasisAnimalsCell Line, TumorFemaleHumansInflammationInterleukinsMiceMice, Inbred BALB CAntibodies, Monoclonal, Murine-DerivedAntibodies, NeutralizingIL26 protein, humanInterleukinschronic inflammatory diseasesInterleukin-26monoclonal antibodyneutralizationpsoriasis

Identifiers

PMID31397631
PMCPMC6816435
OpenAlexW2967002278

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.