Evidence map›Paper›PMID 31397554›Full record

ArticleACS nano2019

Age-Dependent Translocation of Gold Nanoparticles across the Air-Blood Barrier.

Akira Tsuda, Thomas C Donaghey, Nagarjun V Konduru, Georgios Pyrgiotakis, Laura S Van Winkle, Zhenyuan Zhang, Patricia Edwards, Jessica-Miranda Bustamante, Joseph D Brain, Phillip Demokritou

Open access · greenAbstract read
In one paragraph

Article in ACS nano, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 42 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Aerosol pulmonary immune engineering.Advanced drug delivery reviews · 2023
    Review
  7. Review
  8. Article
  9. Serum apolipoprotein A-I depletion is causative to silica nanoparticles-induced cardiovascular damage.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  10. Review
  11. Article
  12. Article
  13. Neurotoxicology of Nanomaterials.Chemical research in toxicology · 2020
    Review
  14. Human brain microvascular endothelial cell pairs model tissue-level blood-brain barrier function.Integrative biology : quantitative biosciences from nano to macro · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Akira TsudaDepartment of Environmental Health , Harvard T. H. Chan School of Public Health , Boston , Massachusetts 02115 , United States.ORCID 0000-0003-4542-1573
Thomas C DonagheyDepartment of Environmental Health , Harvard T. H. Chan School of Public Health , Boston , Massachusetts 02115 , United States.
Nagarjun V KonduruDepartment of Environmental Health , Harvard T. H. Chan School of Public Health , Boston , Massachusetts 02115 , United States.
Georgios PyrgiotakisDepartment of Environmental Health , Harvard T. H. Chan School of Public Health , Boston , Massachusetts 02115 , United States.
Laura S Van WinkleCenter for Health and the Environment , University of California, Davis , Davis , California 95616 , United States.
Zhenyuan ZhangDepartment of Environmental Health , Harvard T. H. Chan School of Public Health , Boston , Massachusetts 02115 , United States.
Patricia EdwardsCenter for Health and the Environment , University of California, Davis , Davis , California 95616 , United States.
Jessica-Miranda BustamanteCenter for Health and the Environment , University of California, Davis , Davis , California 95616 , United States.
Joseph D BrainDepartment of Environmental Health , Harvard T. H. Chan School of Public Health , Boston , Massachusetts 02115 , United States.
Phillip DemokritouDepartment of Environmental Health , Harvard T. H. Chan School of Public Health , Boston , Massachusetts 02115 , United States.
Harvard University · USUniversity of California, Davis · US

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI Gary Adamkiewicz · 1985 to 2026
$44.6M
UC Davis Environmental Health Sciences Core CenterP30ES023513 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Nicholas J. KENYON · 2015 to 2026
$26.0M
UC Davis Biology ProgramR25GM056765 · NIGMS · UNIVERSITY OF CALIFORNIA DAVIS · PI GOMES, ALDRIN V. · 1998 to 2019
$9.7M
ENVIRONMENTAL TOXICOLOGYT32ES007059 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI Laura S Van Winkle · 1985 to 2026
$7.9M
Adult Tissue Morphogenesis: Functional Regulation of Intussusceptive AngiogenesisR01HL094567 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MENTZER, STEVEN · 2009 to 2016
$3.2M
Respiratory and Ocular Toxicity of Inhaled NanomaterialsU01ES027288 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI PINKERTON, KENT ED, THOMASY, SARA MICHELLE · 2016 to 2020
$2.2M
Lipoprotein Corona Fingerprints: Implications for Pulmonary Clearance and Toxicity of Engineered NanoparticlesR00ES025813 · NIEHS · UNIVERSITY OF TEXAS HLTH CTR AT TYLER · PI KONDURU VENKATA, NAGARJUN · 2019 to 2021
$747k
Acquisition of a Cytoviva hyperspectral microscopy systemS10OD021789 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI VAN WINKLE, LAURA S · 2017 to 2017
$226k
Lipoprotein Corona Fingerprints: Implications for Pulmonary Clearance and Toxicity of Engineered NanoparticlesK99ES025813 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI KONDURU VENKATA, NAGARJUN · 2016 to 2017
$204k
NHLBI NIH HHS R01 HL094567NIEHS NIH HHS K99 ES025813NIEHS NIH HHS P30 ES000002NIEHS NIH HHS P30 ES023513NIEHS NIH HHS R00 ES025813NIEHS NIH HHS T32 ES007059NIEHS NIH HHS U01 ES027288NIGMS NIH HHS R25 GM056765NIH HHS S10 OD021789
6 · The paper itself

Abstract

Do immature lungs have air-blood barriers that are more permeable to inhaled nanoparticles than those of fully developed mature lungs? Data supporting this notion and explaining the underlying mechanisms do not exist as far as we know. Using a rat model of postnatal lung development, here the data exactly supporting this notion, that is, significantly more gold nanoparticles (NPs) cross from the air space of the lungs to the rest of the body in neonates than in adults, are presented. Moreover, in neonates the translocation of gold NPs is not size dependent, whereas in adult animals smaller NPs cross the air-blood lung barrier much more efficiently than larger NPs. This difference in air-blood permeability in neonate

Indexed as

AgingAnimalsAnimals, NewbornBlood-Air BarrierGoldLungMetal NanoparticlesRats, WistarGoldair−blood lung barrierE-cadherininfantnanoparticlesparacellular transport routepostnatal developing lungtranslocation

Identifiers

PMID31397554
PMCPMC6929694
OpenAlexW2968104748

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.