Evidence map›Paper›PMID 31397478›Full record

ArticleJournal of the American Medical Informatics Association : JAMIA2019

A nonparametric updating method to correct clinical prediction model drift.

Sharon E Davis, Robert A Greevy, Christopher Fonnesbeck, Thomas A Lasko, Colin G Walsh, Michael E Matheny

Abstract read
In one paragraph

Article in Journal of the American Medical Informatics Association : JAMIA, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  10. Gaps in artificial intelligence research for rural health in the United States: a scoping review.Journal of the American Medical Informatics Association : JAMIA · 2026
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  16. Emerging algorithmic bias: fairness drift as the next dimension of model maintenance and sustainability.Journal of the American Medical Informatics Association : JAMIA · 2025
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sharon E DavisDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Robert A GreevyDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Christopher FonnesbeckDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Thomas A LaskoDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Colin G WalshDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Michael E MathenyDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveClinical prediction models require updating as performance deteriorates over time. We developed a testing procedure to select updating methods that minimizes overfitting, incorporates uncertainty associated with updating sample sizes, and is applicable to both parametric and nonparametric models. MATERIALS AND

methodsWe describe a procedure to select an updating method for dichotomous outcome models by balancing simplicity against accuracy. We illustrate the test's properties on simulated scenarios of population shift and 2 models based on Department of Veterans Affairs inpatient admissions.

resultsIn simulations, the test generally recommended no update under no population shift, no update or modest recalibration under case mix shifts, intercept correction under changing outcome rates, and refitting under shifted predictor-outcome associations. The recommended updates provided superior or similar calibration to that achieved with more complex updating. In the case study, however, small update sets lead the test to recommend simpler updates than may have been ideal based on subsequent performance. DISCUSSION: Our test's recommendations highlighted the benefits of simple updating as opposed to systematic refitting in response to performance drift. The complexity of recommended updating methods reflected sample size and magnitude of performance drift, as anticipated. The case study highlights the conservative nature of our test.

conclusionsThis new test supports data-driven updating of models developed with both biostatistical and machine learning approaches, promoting the transportability and maintenance of a wide array of clinical prediction models and, in turn, a variety of applications relying on modern prediction tools.

Indexed as

Models, StatisticalStatistics, NonparametricHumansMachine LearningPrognosisRisk Assessmentcalibrationmodel updatingpredictive analytics

Identifiers

PMID31397478
PMCPMC6857513

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.