Evidence map›Paper›PMID 31397166›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2019

Placental growth factor levels in quadriceps muscle are reduced by a Western diet in association with advanced glycation end products.

Asitha T Silva, Farzana Rouf, Oluwayemisi A Semola, Mark E Payton, Pamela C Lovern

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Asitha T SilvaDepartment of Physiological Sciences, Oklahoma State University, Stillwater, Oklahoma.
Farzana RoufDepartment of Mechanical and Aerospace Engineering, Oklahoma State University, Stillwater, Oklahoma.
Oluwayemisi A SemolaDepartment of Physiological Sciences, Oklahoma State University, Stillwater, Oklahoma.
Mark E PaytonDepartment of Statistics, Oklahoma State University, Stillwater, Oklahoma.
Pamela C LovernDepartment of Physiological Sciences, Oklahoma State University, Stillwater, Oklahoma.ORCID 0000-0001-7943-4722
Oklahoma State University · US

Funding

Regulation of placenta growth factor by hemodynamics and reactive oxygen speciesR01HL084494 · NHLBI · OKLAHOMA STATE UNIVERSITY STILLWATER · PI LOVERN, PAMELA C · 2009 to 2013
$1.8M
Regulation of placenta growth factor by hemodynamics and reactive oxygen speciesR56HL084494 · NHLBI · OKLAHOMA STATE UNIVERSITY STILLWATER · PI LOVERN, PAMELA C · 2016 to 2016
$362k
NHLBI NIH HHS R01 HL084494NHLBI NIH HHS R56 HL084494
6 · The paper itself

Abstract

In peripheral artery disease (PAD), atherosclerotic occlusion chronically impairs limb blood flow. Arteriogenesis (collateral artery remodeling) is a vital adaptive response to PAD that protects tissue from ischemia. People with type II diabetes have a high risk of developing PAD and would benefit from arteriogenesis. However, arteriogenesis is suppressed in people with diabetes by a multifaceted mechanism which remains incompletely defined. Upregulation of placental growth factor (PLGF) is a key early step in arteriogenesis. Therefore, we hypothesized that metabolic dysfunction would impair PLGF expression in skeletal muscle. We tested this hypothesis in C57BL/6J and ApoE

Indexed as

Diet, WesternNeovascularization, PhysiologicAnimalsChemokine CCL2Collateral CirculationDisease Models, AnimalDown-RegulationFemaleGlycation End Products, AdvancedHindlimbIschemiaMaleMice, Inbred C57BLMice, Knockout, ApoEPlacenta Growth FactorQuadriceps MuscleCCL2 protein, humanChemokine CCL2Flt1 protein, mouseGlycation End Products, AdvancedPgf protein, mousePlacenta Growth FactorTnf protein, mouseTumor Necrosis Factor-alphaVascular Endothelial Growth Factor Avascular endothelial growth factor A, mouseVascular Endothelial Growth Factor Receptor-1advanced glycation end productsarteriogenesiscollateral arterieshindlimb ischemiaperipheral artery diseaseTNFαtype II diabetes

Identifiers

PMID31397166
PMCPMC6843019
OpenAlexW2968449085

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.