ArticleACS sensors2019
Peroxidase Sensitive Amplifiable Probe for Molecular Magnetic Resonance Imaging of Pulmonary Inflammation.
Open access · greenAbstract read
In one paragraph
Article in ACS sensors, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.5field-weighted citation impact, top 6% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 28 citations in OpenAlex.
- Inflammatory microenvironment-responsive MR imaging contrast agents.Nanomedicine (London, England) · 2025Review
- Molecular Imaging of Pulmonary Fibrosis.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025Review
- Quantitative in Vivo Molecular MRI.Advanced materials (Deerfield Beach, Fla.) · 2024Review
- Small-Molecule Bi-DOTA Complex for High-Performance CT and Spectral CT Bioimaging.Frontiers in oncology · 2022Article
- Multimodal Bone Metastasis-associated Epidermal Growth Factor Receptor Imaging in an Orthotopic Rat Model.Radiology. Imaging cancer · 2021Article
- Highly Efficient Activatable MRI Probe to Sense Myeloperoxidase Activity.Journal of medicinal chemistry · 2021Article
- A DNA-Based MRI Contrast Agent for Quantitative pH Measurement.ACS sensors · 2021Article
- In situ decellularization of a large animal saccular aneurysm model: sustained inflammation and active aneurysm wall remodeling.Journal of neurointerventional surgery · 2021Article
- Activatable Nanoparticles: Recent Advances in Redox-Sensitive Magnetic Resonance Contrast Agent Candidates Capable of Detecting Inflammation.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Advances in functional and molecular MRI technologies in chronic liver diseases.Journal of hepatology · 2020Review
- Improving the reactivity of hydrazine-bearing MRI probes forChemical science · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 2 institutions in 1 country.
Aurora Rodríguez-RodríguezThe Institute for Innovation in Imaging , A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School , Charlestown , Massachusetts 02129 , United States.
Sergey ShuvaevThe Institute for Innovation in Imaging , A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School , Charlestown , Massachusetts 02129 , United States.ORCID 0000-0001-7903-0648
Nicholas RotileThe Institute for Innovation in Imaging , A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School , Charlestown , Massachusetts 02129 , United States.
Chloe M JonesThe Institute for Innovation in Imaging , A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School , Charlestown , Massachusetts 02129 , United States.
Clemens K ProbstDivision of Pulmonary and Critical Care Medicine and the Center for Immunology and Inflammatory Diseases , Massachusetts General Hospital , Boston , Massachusetts 02114 , United States.
Diego Dos Santos FerreiraThe Institute for Innovation in Imaging , A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School , Charlestown , Massachusetts 02129 , United States.ORCID 0000-0003-1505-7950
Katherine Graham-O ReganThe Institute for Innovation in Imaging , A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School , Charlestown , Massachusetts 02129 , United States.
Eszter BorosThe Institute for Innovation in Imaging , A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School , Charlestown , Massachusetts 02129 , United States.ORCID 0000-0002-4186-6586
Rachel S KnipeDivision of Pulmonary and Critical Care Medicine and the Center for Immunology and Inflammatory Diseases , Massachusetts General Hospital , Boston , Massachusetts 02114 , United States.
Jason W GriffithDivision of Pulmonary and Critical Care Medicine and the Center for Immunology and Inflammatory Diseases , Massachusetts General Hospital , Boston , Massachusetts 02114 , United States.
Andrew M TagerDivision of Pulmonary and Critical Care Medicine and the Center for Immunology and Inflammatory Diseases , Massachusetts General Hospital , Boston , Massachusetts 02114 , United States.
Alexei BogdanovDepartment of Radiology , University of Massachusetts Medical School , Worcester , Massachusetts 01655 , United States.
Peter CaravanThe Institute for Innovation in Imaging , A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School , Charlestown , Massachusetts 02129 , United States.ORCID 0000-0002-3179-6537
Massachusetts General Hospital · USUniversity of Massachusetts Chan Medical School · US
Funding
MR SIGNAL AMPLIFICATION FOR RECEPTOR IMAGINGR01EB000858 · NIBIB · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BOGDANOV, ALEXEI A. · 2003 to 2022
$6.0MPET Imaging of Pulmonary FibrosisR01HL131907 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D, LANUTI, MICHAEL · 2016 to 2018
$2.3MUnruptured Intracranial Aneurysms: Rupture-Risk Assessment by Non-Invasive Molecular ImagingR01NS091552 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BOGDANOV, ALEXEI A., GOUNIS, MATTHEW JOHN · 2015 to 2018
$2.1MMolecular fluorescence lifetime sensor of pro-inflammatory signaling in diabetesR01DK095728 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BOGDANOV, ALEXEI A. · 2014 to 2017
$1.5MPET Imaging of Pulmonary FibrosisR01HL116315 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2012 to 2014
$1.3MDistinct Function and Control of Regulatory T Cell Subsets During InfluenzaK08AI125816 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI GRIFFITH, JASON W. · 2017 to 2021
$1.1MRole and regulation of vascular permeability in pulmonary fibrosisK08HL140175 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI KNIPE, RACHEL S · 2018 to 2022
$864kElectronics Upgrade for 11.7 TS10OD025234 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2018 to 2018
$595kHPLC-ICP-MS SystemS10OD010650 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2013 to 2013
$371kNHLBI NIH HHS K08 HL140175NHLBI NIH HHS R01 HL116315NHLBI NIH HHS R01 HL131907NIAID NIH HHS K08 AI125816NIBIB NIH HHS R01 EB000858NIDDK NIH HHS R01 DK095728NIH HHS S10 OD010650NIH HHS S10 OD025234NINDS NIH HHS R01 NS091552
Abstract
An amplifiable magnetic resonance imaging (MRI) probe that combines the stability of the macrocyclic Gd-DOTAGA core with a peroxidase-reactive 5-hydroxytryptamide (5-HT) moiety is reported. The incubation of the complex under enzymatic oxidative conditions led to a 1.7-fold increase in
Indexed as
AnimalsContrast MediaMagnetic Resonance ImagingMicePeroxidasesPneumoniaSerotoninContrast MediaPeroxidasesSerotonin5-hydroxytryptamidecontrast agentgadoliniumMRIpulmonary fibrosis
Identifiers
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.