ArticleJournal of cachexia, sarcopenia and muscle2019
Weight loss in heart failure is associated with increased mortality only in non-obese patients without diabetes.
Article in Journal of cachexia, sarcopenia and muscle, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06298825 (Effect of Sarcopenia on Prognosis of Patients With Acute Decompensated Heart Failure), which is not on this map. Cited by 15 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Sarcopenia on Prognosis of Patients With Acute Decompensated Heart Failure: a Prospective, Multi-center, Observational Cohort Study
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Sarcopenia is linked to higher levels of B-type natriuretic peptide and its N-terminal fragment in heart failure: a systematic review and meta-analysis.European geriatric medicine · 2024Pooled it
- Association of weight loss with cardiovascular or all-cause mortality in patients with heart failure: A meta-analysis.International journal of obesity (2005) · 2024Pooled it
- Association of triglyceride-glucose index trajectories with the risk of worsening heart failure in elderly patients with chronic heart failure and type 2 diabetes: a competing risk analysis.Cardiovascular diabetology · 2025Article
- Clinical implication of sarcopenia in patients with acute decompensated heart failure: Design and rationale.ESC heart failure · 2025Observational
- Prognostic influence of weight loss on overweight/obese young heart failure patients.Saudi medical journal · 2024Article
- Review
- Association of weight change and in-hospital mortality in patients with repeated hospitalization for heart failure.Journal of cachexia, sarcopenia and muscle · 2023Observational
- The Obesity Paradox in Chronic Heart Disease and Chronic Obstructive Pulmonary Disease.Cureus · 2022Review
- A year in heart failure: an update of recent findings.ESC heart failure · 2021Review
- Weight loss, malnutrition, and cachexia in COVID-19: facts and numbers.Journal of cachexia, sarcopenia and muscle · 2021Article
- Heart failure in the last year: progress and perspective.ESC heart failure · 2020Review
- Comment on 'Weight loss in heart failure is associated with increased mortality only in non-obese patients without diabetes' by Niedziela et al.Journal of cachexia, sarcopenia and muscle · 2020Article
- Does Weight Loss Improve Clinical Outcomes in Overweight and Obese Patients with Heart Failure?Current diabetes reports · 2020Review
- Muscle Wasting and Sarcopenia in Heart Failure-The Current State of Science.International journal of molecular sciences · 2020Review
- Weight loss in heart failure is associated with increased mortality only in non-obese patients without diabetes.Journal of cachexia, sarcopenia and muscle · 2019Article
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6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWeight loss (WL) is an independent predictor of mortality in patients with heart failure (HF). Moderate WL is recommended for overweight or obese patients with type 2 diabetes mellitus (DM). The aim of this study was to assess the prognostic impact of body weight reduction on survival in patients with both HF with reduced ejection fraction (HFrEF) and DM.
methodsThe study comprised patients with HFrEF at the outpatient clinic. WL was defined as a body weight reduction of at least 7.5% during at least 6 months. Clinical features and 1 year mortality were analysed in WL and DM groups. Multivariate regression model was chosen to assess the predictive role of WL in HF patients with and without DM. The analysis regarding obesity before HF was also performed.
resultsThe study comprised 777 patients with HFrEF. Mean age was 53.2 ± 9.2, 12.0% were women, mean EF was 23.7 ± 6.0 %, and New York Heart Association III or IV class, DM, and WL were found in 60.5%, 33.3%, and 47.1% patients, respectively. WL was more prevalent in diabetic patients, comparing with those without DM (53.7% vs. 43.8%, respectively, 0.01), and was associated with higher 1 year mortality only in non-diabetic group (17.6% for WL vs. 8.2% for non-WL, log-rank 0.001). In the multivariate analysis, WL was associated with a higher risk of 1 year mortality in non-diabetic patients: HR 1.76 (1.05-2.95), 0.03 and only in the subgroup without obesity: HR 2.35 (1.28-4.32), 0.006. In non-diabetic patients with obesity and in diabetic patients regardless of weight status, WL was not associated with worse prognosis (thereof, WL was excluded from the multivariate models).
conclusionsOverall, WL in HFrEF has emerged as a predictor of unfavourable outcomes only in non-obese patients without DM. More importantly, this study has identified that the presence of DM (irrespective of weight status) or the presence of obesity in non-diabetic patients abolished the unfavourable impact of WL on long-term outcomes.
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