Evidence map›Paper›PMID 31397036›Full record

ReviewJournal of neuroendocrinology2020

Risk factors of neurovascular ageing in women.

Virginia M Miller, Muthuvel Jayachandran, Jill N Barnes, Michelle M Mielke, Kejal Kantarci, Walter A Rocca

Abstract readReview
In one paragraph

Review in Journal of neuroendocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Integrative cardiovascular control in women: Regulation of blood pressure, body temperature, and cerebrovascular responsiveness.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Review
  8. Risk factors of neurovascular ageing in women.Journal of neuroendocrinology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Virginia M MillerDepartments of Surgery and Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0003-1251-1388
Muthuvel JayachandranDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Jill N BarnesDepartment of Kinesiology, University of Wisconsin-Madison, Madison, WI, USA.
Michelle M MielkeDivision of Epidemiology, Department of Health Sciences Research and Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Kejal KantarciDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Walter A RoccaDivision of Epidemiology, Department of Health Sciences Research and Department of Neurology, Mayo Clinic, Rochester, MN, USA.

Funding

MAYO CLINIC CENTER FOR TRANSLATIONAL SCIENCE ACTIVITIESUL1RR024150 · NCRR · MAYO CLINIC ROCHESTER · PI RIZZA, ROBERT A. · 2006 to 2011
$66.4M
SUPPLEMENT TO ALZHEIMERS DISEASE PATIENT REGISTRYU01AG006786 · NIA · MAYO CLINIC ROCHESTER · PI GRAFF-RADFORD, JONATHAN, JACK, CLIFFORD R. · 1986 to 2023
$49.6M
SEX STEROIDS, GROWTH FACTORS, &BONE CELL FUNCTIONP01AG004875 · NIA · MAYO CLINIC ROCHESTER · PI MONROE, DAVID G · 1985 to 2019
$30.8M
Prevention of Alzheimer's disease in women: risks and benefits of hormone therapyRF1AG057547 · NIA · MAYO CLINIC ROCHESTER · PI GLEASON, CAREY E, KANTARCI, KEJAL · 2017 to 2020
$11.1M
Rochester Epidemiology ProjectR01AG034676 · NIA · MAYO CLINIC ROCHESTER · PI ROCCA, WALTER A, ST SAUVER, JENNIFER LYNN · 2010 to 2019
$9.5M
Sex-Specific Effects of Endocrine Disruption on Aging and Alzheimer's DiseaseU54AG044170 · NIA · MAYO CLINIC ROCHESTER · PI KAPOOR, EKTA · 2018 to 2022
$7.7M
Mayo Clinic Interdisciplinary Women's Health Research ProgramK12HD065987 · NICHD · MAYO CLINIC ROCHESTER · PI KANTARCI, KEJAL · 2010 to 2023
$6.7M
Sex-specific Risk for Vascular Dysfunction and Cognitive DeclineP50AG044170 · NIA · MAYO CLINIC ROCHESTER · PI MILLER, VIRGINIA M · 2012 to 2017
$6.1M
Reproductive risk factors for Alzheimer's disease dementia and pathologyRF1AG055151 · NIA · MAYO CLINIC ROCHESTER · PI MIELKE, MICHELLE M, ROCCA, WALTER A · 2017 to 2017
$4.0M
Interdisciplinary Infrastructure for Aging Research: Rochester Epidemiology ProjectR33AG058738 · NIA · MAYO CLINIC ROCHESTER · PI LEBRASSEUR, NATHAN K, OLSON, JANET E · 2020 to 2022
$2.4M
Estrogen, Platelets, and ArtherosclerosisR01HL090639 · NHLBI · MAYO CLINIC ROCHESTER · PI BAILEY, KENT R, MILLER, VIRGINIA M · 2008 to 2012
$1.9M
Cerebral blood flow, connectivity and cognition: the effect of age and exerciseR00HL118154 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI BARNES, JILL NICOLE · 2015 to 2017
$735k
NCRR NIH HHS UL1 RR024150NHLBI NIH HHS K99 HL118154NHLBI NIH HHS R00 HL118154NHLBI NIH HHS R01 HL090639NIA NIH HHS P01 AG004875NIA NIH HHS P50 AG044170NIA NIH HHS R01 AG034676NIA NIH HHS R33 AG058738NIA NIH HHS RF1 AG055151NIA NIH HHS RF1 AG057547NIA NIH HHS U01 AG006786NIA NIH HHS U54 AG044170NICHD NIH HHS K12 HD065987NIH HHS P01 AG004875NIH HHS R01 AG034676NIH HHS R21 NS066147NIH HHS U01 AG006786NIH HHS UL1 RR024150NINDS NIH HHS R21 NS066147
6 · The paper itself

Abstract

Biological sex and changes in sex hormones throughout life influence all aspects of health and disease. In women, changes in sex hormonal status reflect ovarian function, pregnancy and the use of exogenous hormonal treatments. Longitudinal data from defined cohorts of women will help to identify mechanisms by which the hormonal milieu contributes to cerebrovascular ageing, brain structure and ultimately cognition. This review summarises the phenotypes of three cohorts of women identified through the medical records-linkage system of the Rochester Epidemiology Project and the Mayo Clinic Specialized Center of Research Excellence (SCORE) on Sex Differences: (i) menopausal women with histories of normotensive or hypertensive pregnancies; (ii) women who had bilateral oophorectomy ≤45 years of age; and (iii) women who experienced natural menopause and used menopausal hormone treatments for 4 years. Data from these cohorts will influence the design of follow-up studies concerning how sex hormonal status affects neurovascular ageing in women.

Indexed as

AdultAgingBlood PressureBrainFemaleHumansMenopauseMiddle AgedPremenopauseRisk Factorsaortic blood pressurebrain volumecognitionmenopauseoestradiolpregnancywhite matter hyperintensities

Identifiers

PMID31397036
PMCPMC6982564

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.