Evidence map›Paper›PMID 31396962›Full record

ArticleThe Journal of comparative neurology2020

Dual recombinase fate mapping reveals a transient cholinergic phenotype in multiple populations of developing glutamatergic neurons.

Nailyam Nasirova, Lely A Quina, Ibis M Agosto-Marlin, Jan-Marino Ramirez, Evelyn K Lambe, Eric E Turner

Open access · greenAbstract read
In one paragraph

Article in The Journal of comparative neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 37 citations in OpenAlex.

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  7. Xanomeline restores endogenous nicotinic acetylcholine receptor signaling in mouse prefrontal cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
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  20. The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Nailyam NasirovaCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington.
Lely A QuinaCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington.
Ibis M Agosto-MarlinCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington.
Jan-Marino RamirezCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington.
Evelyn K LambeDepartment of Physiology, Obstetrics and Gynecology, and Psychiatry, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-5994-6090
Eric E TurnerCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington.ORCID 0000-0001-5499-6788
Seattle Children's Hospital · USUniversity of Toronto · CAUniversity of Washington · US

Funding

Integrative Consequences of HypoxiaP01HL090554 · NHLBI · UNIVERSITY OF CHICAGO · PI PRABHAKAR, NANDURI R · 2008 to 2017
$21.4M
Mechanisms Underlying Sympathetic Activation-dependent Endothelial Cell Activation by Chronic Intermittent HypoxiaP01HL144454 · NHLBI · UNIVERSITY OF CHICAGO · PI PRABHAKAR, NANDURI R · 2019 to 2023
$12.7M
Mechanisms of Brain Dysmorphology in MN1 C-Terminal Truncation Syndrome, a Novel Intellectual Developmental Disability Disorder P50HD103524 · NICHD · UNIVERSITY OF WASHINGTON · PI DANIEL DOHERTY · 2020 to 2026
$9.9M
Unraveling respiratory rhythm generation in the medullary networkR01HL126523 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI Jan M. Ramirez · 2015 to 2026
$8.3M
Intellectual and Developmental Disabilities Research CenterU54HD083091 · NICHD · UNIVERSITY OF WASHINGTON · PI GURALNICK, MICHAEL J · 2014 to 2019
$7.9M
Unraveling the dynamic mechanisms underlying opioid respiratory depressionR01HL144801 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI Jan M. Ramirez · 2019 to 2026
$5.2M
Putting habenula pathways on the mapR01MH093667 · NIMH · SEATTLE CHILDREN'S HOSPITAL · PI TURNER, ERIC E. · 2011 to 2019
$3.6M
Neuroglial interactions underlying the generation of the sighR01HL151389 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI RAMIREZ, JAN M. · 2020 to 2023
$3.2M
Functional studies of the medial habenula in models of reward and mood disordersR01DA035838 · NIDA · SEATTLE CHILDREN'S HOSPITAL · PI TURNER, ERIC E. · 2014 to 2018
$2.1M
Developmental pathways in the nervous systemR01MH065496 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TURNER, ERIC E. · 2003 to 2007
$1.7M
NHLBI NIH HHS P01 HL090554NHLBI NIH HHS P01 HL144454NHLBI NIH HHS R01 HL126523NHLBI NIH HHS R01 HL144801NHLBI NIH HHS R01 HL151389NICHD NIH HHS P50 HD103524NICHD NIH HHS U54 HD083091NIDA NIH HHS R01 DA035838NIMH NIH HHS R01 MH065496NIMH NIH HHS R01 MH093667
6 · The paper itself

Abstract

Cholinergic transmission shapes the maturation of glutamatergic circuits, yet the developmental sources of acetylcholine have not been systematically explored. Here, we have used Cre-recombinase-mediated genetic labeling to identify and map both mature and developing CNS neurons that express choline acetyltransferase (ChAT). Correction of a significant problem with a widely used Chat

Indexed as

AcetylcholineAnimalsBrainCholine O-AcetyltransferaseMiceMice, Mutant StrainsNeurogenesisNeuronsRecombinasesAcetylcholineCholine O-AcetyltransferaseRecombinasesacetylcholinecholine acetyltransferaseglutamateRRID: AB_2064130RRID: AB_2068524RRID: AB_2079751RRID: AB_2209751RRID: AB_2576200

Identifiers

PMID31396962
PMCPMC6889053
OpenAlexW2968824051

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.