Evidence map›Paper›PMID 31396937›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2019

In Vitro Differentiation of T Cells from Murine Pluripotent Stem Cells.

Xiaoniao Chen, Fengyang Lei, Liqiang Wang, Xiaofang Xiong, Jianxun Song

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiaoniao ChenDepartment of Ophthalmology, Chinese PLA General Hospital, Beijing, China.
Fengyang LeiDepartment of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Liqiang WangDepartment of Ophthalmology, Chinese PLA General Hospital, Beijing, China.
Xiaofang XiongDepartment of Microbial Pathogenesis and Immunology, Texas A&M University, Bryan, TX, USA.
Jianxun SongDepartment of Microbial Pathogenesis and Immunology, Texas A&M University, Bryan, TX, USA. jus35@tamu.edu.

Funding

Nucleus Accumbens-Associated Protein-1 in Melanoma ImmunotherapyR01CA221867 · NCI · UNIVERSITY OF KENTUCKY · PI SONG, JIANXUN JIM, YANG, JIN-MING · 2018 to 2023
$2.8M
Stem cell-derived regulatory T cells for therapeutic use in arthritisR01AI121180 · NIAID · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI SONG, JIANXUN JIM · 2016 to 2020
$1.9M
Directed differentiation of HBV-specific CTL from iPSC for cell-based therapiesR21AI109239 · NIAID · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SONG, JIANXUN JIM · 2014 to 2015
$441k
Role of stem cell-derived T lymphocytes in chronic HBV infectionR21AI128325 · NIAID · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI SONG, JIANXUN JIM · 2017 to 2018
$419k
NCI NIH HHS R01 CA221867NIAID NIH HHS R01 AI121180NIAID NIH HHS R21 AI109239NIAID NIH HHS R21 AI128325
6 · The paper itself

Abstract

In recent years cancer immunotherapy, especially the cell-based immunotherapy, has reached several milestones and achieved a lot of cancer remission in the clinics. Obtaining a more potent and effective cytotoxic T lymphocytes (CTLs) for cancer immunotherapy is always the ultimate goal for the researchers. However, the difficulty in harvesting a large number of tumor antigen-specific CTLs from the tumor patient is still a major obstacle we need to overcome. In our previous studies, it is shown that pluripotent stem cell-derived CTL-especially the genetically engineered antigen-specific CTLs-may serve as a good source of unlimited number of highly reactive and antigen-specific CTLs. Here we present a two-step method for the generation of antigen-specific T lymphocytes from iPS cells by in vitro priming and in vivo maturation.

Indexed as

AnimalsAntigens, NeoplasmCalcium-Binding ProteinsCell Culture TechniquesCell DifferentiationCell Line, TumorCoculture TechniquesCulture MediaDisease Models, AnimalFemaleFlow CytometryGenetic VectorsHomeodomain ProteinsHumansImmunotherapy, AdoptiveInduced Pluripotent Stem CellsAntigens, NeoplasmCalcium-Binding ProteinsCulture MediaDlk1 protein, mouseHomeodomain ProteinsRAG-1 proteinReceptors, Antigen, T-CellRecombinant ProteinsDifferentiationInduced pluripotent stem cellsNotch signalingStem cell biologyT cells

Identifiers

PMID31396937
PMCPMC7029810

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.