Trial reportJournal of general internal medicine2019
Electronic Pill Bottles or Bidirectional Text Messaging to Improve Hypertension Medication Adherence (Way 2 Text): a Randomized Clinical Trial.
Trial report in Journal of general internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02778542 (Bidirectional Text Messaging for Measurement and Motivation of Medication Adherence in Hypertension, a Pilot Study), which is not on this map. Cited by 22 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Bidirectional Text Messaging for Measurement and Motivation of Medication Adherence in Hypertension, a Pilot Study
Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Managing cardiovascular risk factors with telemedicine in primary care: A systematic review and meta-analysis of patients with arterial hypertension and type 2 diabetes.Chronic illness · 2025Pooled it
- Effectiveness of digital health interventions for telemedicine/telehealth for managing blood pressure in adults: a systematic review and meta-analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Pooled it
- Effect of electronic adherence monitoring on adherence and outcomes in chronic conditions: A systematic review and meta-analysis.PloS one · 2022Pooled it
- Effectiveness of Text Messaging Interventions on Blood Pressure Control Among Patients With Hypertension: Systematic Review of Randomized Controlled Trials.JMIR mHealth and uHealth · 2021Pooled it
- A pilot randomized clinical trial of gamification to increase medication adherence.American heart journal · 2026 · on this mapTrial
- Behavioral Economic Framing for Enrollment and Retention of Patients in Remote Blood Pressure Monitoring: A Randomized Clinical Trial.JAMA network open · 2025Trial
- Improvement of non-adherence and reduction of BP values in patients with difficult-to-treat hypertension: the ATHAN clinical trial.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Trial
- Remote Blood Pressure Monitoring With Social Support for Patients With Hypertension: A Randomized Clinical Trial.JAMA network open · 2024Trial
- Feasibility and outcomes from using a commitment device and text message reminders to increase adherence to time-restricted eating: A randomized trial.American heart journal · 2023Trial
- Effect of Financial Incentives for Process, Outcomes, or Both on Cholesterol Level Change: A Randomized Clinical Trial.JAMA network open · 2021Trial
- Patient Interaction Phenotypes With an Automated Remote Hypertension Monitoring Program and Their Association With Blood Pressure Control: Observational Study.Journal of medical Internet research · 2020Trial
- A randomized clinical trial of an interactive voice response and text message intervention for individuals with hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2020Trial
- Predicting Autopsy-Confirmed Neuropathology across Clinical, Neuroimaging, and CSF Biomarkers using Machine Learning.bioRxiv : the preprint server for biology · 2026Article
- Network meta analysis of contributions by different healthcare practitioners in digital self care for hypertension.NPJ digital medicine · 2025Review
- Electronic health records-integrated mobile health interventions in primary care to improve hypertension management in Black/African American populations: a systematic review.Oxford open digital health · 2025Article
- Engagement in mHealth-Prompted Self-Measured Blood Pressure Monitoring Among Participants Recruited From a Safety-Net Emergency Department: Secondary Analysis of the Reach Out Trial.JMIR mHealth and uHealth · 2024Article
- Measurement Tools and Utility of Hair Analysis for Screening Adherence to Antihypertensive Medication.Global heart · 2023Review
- Impact of Electronic Medication Reminder Caps on Patient Adherence and Blood Pressure.The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians · 2021Article
- Effect of the ExactCare medication care management model on adherence, health care utilization, and costs.Journal of managed care & specialty pharmacy · 2021Article
- Optimizing an Obesity Treatment Using the Multiphase Optimization Strategy Framework: Protocol for a Randomized Factorial Trial.JMIR research protocols · 2021Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundPoor medication adherence contributes to inadequate control of hypertension. However, the value of adherence monitoring is unknown.
objectiveTo evaluate the impact of monitoring adherence with electronic pill bottles or bidirectional text messaging on improving hypertension control.
designThree-arm pragmatic randomized controlled trial. PATIENTS: One hundred forty-nine primary care patients aged 18-75 with hypertension and text messaging capabilities who were seen at least twice in the prior 12 months with at least two out-of-range blood pressure (BP) measurements, including the most recent visit.
interventionsPatients were randomized in a 1:2:2 ratio to receive (1) usual care, (2) electronic pill bottles for medication adherence monitoring (pill bottle), and (3) bidirectional text messaging for medication adherence monitoring (bidirectional text). MAIN MEASURES: Change in systolic BP during the final 4-month visit compared with baseline. KEY
resultsAt the 4-month follow-up visit, mean (SD) change values in systolic blood pressure were - 4.7 (23.4) mmHg in usual care, - 4.3 (21.5) mmHg in the pill bottle arm, and - 4.6 (19.8) mmHg in the text arm. There was no significant change in systolic blood pressure between control and the pill bottle arm (p = 0.94) or the text messaging arm (p = 1.00), and the two intervention arms did not differ from each other (p = 0.93).
conclusionsDespite good measured adherence, neither feedback with electronic pill bottles nor bidirectional text messaging about medication adherence improved blood pressure control. Adherence to prescribed medications was not improved enough to affect BP control or it was not the primary driver of poor control.
trial registrationclinicaltrials.gov (NCT02778542).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.