ArticlePediatric surgery international2019
Safety and efficacy of mucous fistula refeeding in low-birth-weight infants with enterostomies.
Article in Pediatric surgery international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Mucous Fistula Refeeding in Newborns: Why, When, How, and Where? Insights from a Systematic Review.Nutrients · 2025Pooled it
- Efficacy and safety of mucous fistula refeeding in preterm infants: an exploratory randomized controlled trial.BMC pediatrics · 2023Trial
- Sepsis profile among preterm infants with enterostomy and fecal transfer: a multicenter retrospective cohort study.Molecular and cellular pediatrics · 2026Article
- Flow efficiency of 3D-printed refeeding tubes in a simulated neonatal high-output stoma model.Pediatric surgery international · 2026Article
- Article
- Clinical guideline for postoperative nutrition support in neonates with enterostomy (2024).Pediatric investigation · 2025Article
- Chyme reinfusion practices in the neonatal population.Pediatric surgery international · 2024Article
- MUC-FIRE: Study protocol for a randomized multicenter open-label controlled trial to show that MUCous FIstula REfeeding reduces the time from enterostomy closure to full enteral feeds.Contemporary clinical trials communications · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the safety and efficacy of mucous fistula refeeding (MFR) in low-birth-weight infants.
methodsBetween December 2006 and December 2018, medical records of low-birth-weight infants who underwent small bowel enterostomy formation in the neonatal period and subsequent stoma closure at our institution were retrospectively reviewed. Patients were assigned to "refeeding" (RF) and "non-refeeding" (NRF) groups, which were compared for patient characteristics and clinical outcomes. We also cultured the proximal stoma output over time in the RF group and reviewed changes in the flora to evaluate the safety of refeeding.
resultsIn the RF group, compared with that before refeeding, there was significantly more rapid weight gain after refeeding (17.7 vs 10.6 g/day; P = 0.002). Median total time of parenteral nutrition (PN) was 25 and 87 days in the RF and NRF groups, respectively (P = 0.001). The number of patients who developed PN-associated liver disease (PNALD) was smaller in the RF group (P = 0.12). No complications of MFR were noted and no pathogenic bacteria were cultured.
conclusionMFR was able to diminish the need for PN, which potentially decreased the incidence of PNALD, and was safe as there were no complications of the refeeding process.
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