Evidence map›Paper›PMID 31396714›Full record

ArticleParasitology research2019

A high number of pfmdr1 gene copies in P. falciparum from Venezuela.

César Pacheco, Jorge Moreno, Flor Herrera

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In one paragraph

Article in Parasitology research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
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  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

César PachecoInstituto de Investigaciones Biomédicas (BIOMED), Facultad de Ciencias de la Salud, Universidad de Carabobo, Núcleo Aragua, Maracay, 2101, Venezuela.
Jorge MorenoCentro de Investigaciones de Campo "Dr. Francesco Vitanza", Servicio Autónomo Instituto de Altos Estudios "Dr. Arnoldo Gabaldon", MPPS, Tumeremo, Bolívar, Venezuela.
Flor HerreraInstituto de Investigaciones Biomédicas (BIOMED), Facultad de Ciencias de la Salud, Universidad de Carabobo, Núcleo Aragua, Maracay, 2101, Venezuela. flormhq@gmail.com.ORCID http://orcid.org/0000-0001-7785-6497
University of Carabobo · VEInstituto de Estudios Avanzados · VE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multidrug resistance in Plasmodium falciparum has been associated with gene amplification of pfmdr1. We studied the corresponding gene amplification in P. falciparum from blood samples of malaria patients in the Sifontes Municipality, Bolívar State, Venezuela, known as the highest region of incidence of malaria. Fifty-five P. falciparum DNA samples were extracted from different hosts and used for qPCR assessment of the copy number of pfmdr1. The assay detected four copies of the multidrug-resistant line P. falciparum Dd2 in comparison with the P. falciparum 3D7 that had only one copy. In the patients' samples, the copy number of pfmdr1 was a single copy in 80% and 20% left distributed in different copy numbers up to seven.

Indexed as

AntimalarialsATP-Binding Cassette, Sub-Family C ProteinsDrug Resistance, MultipleGene AmplificationGene DosageHumansMalaria, FalciparumPlasmodium falciparumProtozoan ProteinsVenezuelaAntimalarialsATP-Binding Cassette, Sub-Family C ProteinsMdr1 protein, Plasmodium falciparumProtozoan ProteinsMalariaP. falciparumpfmdr1 geneVenezuela

Identifiers

PMID31396714
OpenAlexW2965017977

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.