Evidence map›Paper›PMID 31396713›Full record

ArticleMikrochimica acta2019

Molecularly imprinted gelatin nanoparticles for DNA delivery and in-situ fluorescence imaging of telomerase activity.

Yida Zhang, Yuan Zhang, Chen Ma, Yaya Wang, Shuai Mu, Xiaoyan Liu, Xiaoyu Zhang, Haixia Zhang

Abstract read
PubMed Publisher
In one paragraph

Article in Mikrochimica acta, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yida ZhangCollege of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, China.
Yuan ZhangCollege of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, China.
Chen MaCollege of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, China.
Yaya WangCollege of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, China.
Shuai MuCollege of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, China.
Xiaoyan LiuCollege of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, China.
Xiaoyu ZhangSchool of Basic Medical Science, Lanzhou University, Lanzhou, 730000, China. zhangxyu@lzu.edu.cn.
Haixia ZhangCollege of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, China. zhanghx@lzu.edu.cn.ORCID 0000-0002-6927-4662

Funding

National Natural Science Foundation of China 21575055the Research Funds for the Central Universities lzujbky-2017-k09
6 · The paper itself

Abstract

DNA-loaded molecularly imprinted gelatin nanoparticles (GDMI-NPs) were prepared to deliver the Cy3- and Cy5-labelled DNA probe to a tumor region. This allows the activity of telomerase can be detected over 3-400 cells with a low detection limit (3 cells). Fluorescence images were acquired at an excitation wavelength of 535 nm and the emission from the green channel (550-580 nm; label Cy3) and the red channel (650-680 nm; label Cy5). HeLa cells and HepG2 cells were both used to test the performance of GDMI-NPs. Experimental results confirmed the GDMI-NPs has hardly retained in liver and spleen tissue, and its circulated time was longer than that of non-imprinted nanoparticles in blood. The ability of GDMI-NPs to resist immuno stress and anti-macrophage phagocytosis shows great potential for cancer diagnosis and as a drug carrier. Graphical abstract Highly DNA-loaded molecularly imprinted gelatin nanoparticles (GDMI-NPs) were prepared to deliver the Cy3-labelled DNA probe to a cancer region, and realization of telomerase in situ fluorescence imaging at the tumor site.

Indexed as

Molecular ImprintingDNADrug CarriersGelatinHeLa CellsHep G2 CellsHumansNanoparticlesOptical ImagingTelomeraseDNADrug CarriersGelatinTelomeraseGene deliveryImmunological stressMolecular imprintingProtein coronasTransferrin

Identifiers

PMID31396713

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.