ArticleJournal of neurology2019
Cervical myogenic potentials and controlled postural responses elicited by a prototype vestibular implant.
Article in Journal of neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 22 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
VertiGO! - Get up and GO! With the Vestibular Implant
Electrical Stimulation of the Peripheral Vestibular System in Order to Develop a Vestibular Implant
Who cites it
22 citing papers in PubMed.
- Vestibular implant stimulation can improve self-motion perception.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Vestibular electrode position stability over time.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- The evolution of vestibular function and health-related quality of life in bilateral vestibulopathy.Scientific reports · 2025Article
- Review
- Optimizing vestibular implant electrode positioning using fluoroscopy and intraoperative CT imaging.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
- Mechanisms underlying treatment effects of vestibular noise stimulation on postural instability in patients with bilateral vestibulopathy.Journal of neurology · 2024Article
- Subconscious vibrotactile stimulation improves mobility and balance in patients with bilateral vestibulopathy: adherence over 2 years.Frontiers in neurology · 2024Article
- Thirty years with cervical vestibular myogenic potentials: a critical review on its origin.Frontiers in neurology · 2024Review
- Article
- Bilateral vestibulopathy: a clinical update and proposed diagnostic algorithm.Frontiers in neurology · 2023Review
- Vestibular prosthesis: from basic research to clinics.Frontiers in integrative neuroscience · 2023Review
- Bilateral vestibulopathy patients' perspectives on vestibular implant treatment: a qualitative study.Journal of neurology · 2022Article
- Optimized Signal Analysis to Quantify the Non-Linear Behaviour of the Electrically Evoked Vestibulo-Ocular Reflex in Patients with a Vestibular Implant.Audiology & neuro-otology · 2022Article
- Vestibular function in children with cochlear implant: Impact and evaluation.Frontiers in neurology · 2022Review
- New Frontiers in Managing the Dizzy Patient.Otolaryngologic clinics of North America · 2021Review
- An Implanted Vestibular Prosthesis Improves Spatial Orientation in Animals with Severe Vestibular Damage.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Differences in Vestibular-Evoked Myogenic Potential Responses by Using Cochlear Implant and Otolith Organ Direct Stimulation.Frontiers in neurology · 2021Article
- Simultaneous activation of multiple vestibular pathways upon electrical stimulation of semicircular canal afferents.Journal of neurology · 2020Article
- Introducing the DizzyQuest: an app-based diary for vestibular disorders.Journal of neurology · 2020Article
- Influence of systematic variations of the stimulation profile on responses evoked with a vestibular implant prototype in humans.Journal of neural engineering · 2020Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gaze stabilization and postural control are two key functions of the vestibular system. In consequence, oscillopsia and chronic imbalance are the two main complaints of patients presenting with a severe bilateral vestibular function loss. The vestibular implant is emerging as a promising treatment for this group of patients whose quality of life is significantly impaired. Although the final aim of the vestibular implant should be to restore vestibular function as a whole, until now the research has focused mainly on the restoration of the vestibulo-ocular reflex to improve gaze stabilization. In this study, we aimed to explore whether the vestibulo-collic and vestibulo-spinal pathways could be activated and controlled with the electrical stimuli provided by our vestibular implant prototype. This was first explored and demonstrated with recordings of electrically elicited cervical vestibular evoked myogenic potentials (ecVEMPs). ecVEMPs with characteristics similar to the classical acoustically elicited cervical vestibular evoked myogenic potentials (cVEMPs) were successfully evoked in five out of the eight tested patients. Amplitudes of the electrically elicited N-P complex varied, ranging from 44 to 120 µV. Mean latencies of the N and P waves were of 9.71(± 1.17) ms and 17.24 ms (± 1.74), respectively. We also evaluated the possibility of generating controlled postural responses using a stepping test. Here, we showed that controlled and consistent whole-body postural responses can be effectively obtained with rapid changes in the "baseline" (constant rate and amplitude) electrical activity delivered by the vestibular implant in two out of the three tested subjects. Furthermore, obtained amplitude of body rotations was significantly correlated with the intensity of stimulation and direction of body rotations correlated with the side of the delivered stimulus (implanted side). Altogether, these data suggest that the vestibular implant could also be used to improve postural control in patients with bilateral vestibulopathy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.