Evidence map›Paper›PMID 31396661›Full record

ArticleDiabetologia2019

Dietary inflammatory index and type 2 diabetes risk in a prospective cohort of 70,991 women followed for 20 years: the mediating role of BMI.

Nasser Laouali, Francesca Romana Mancini, Mariem Hajji-Louati, Douae El Fatouhi, Beverley Balkau, Marie-Christine Boutron-Ruault, Fabrice Bonnet, Guy Fagherazzi

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Diabetologia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 4 pooled it
12.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 4 syntheses or guidelines pooled it, 102 citations in OpenAlex.

  1. Pooled it
  2. Dietary Inflammatory Index in relation to Type 2 Diabetes: A Meta-Analysis.International journal of clinical practice · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Nasser LaoualiCentre for Research in Epidemiology and Population Health (CESP), Inserm (Institut National de la Santé et de la Recherche Médicale) U1018, Generations and Health Across Generations, Gustave Roussy Institute, 114 rue Edouard Vaillant, 94805, Villejuif Cedex, France.
Francesca Romana ManciniCentre for Research in Epidemiology and Population Health (CESP), Inserm (Institut National de la Santé et de la Recherche Médicale) U1018, Generations and Health Across Generations, Gustave Roussy Institute, 114 rue Edouard Vaillant, 94805, Villejuif Cedex, France.
Mariem Hajji-LouatiCentre for Research in Epidemiology and Population Health (CESP), Inserm (Institut National de la Santé et de la Recherche Médicale) U1018, Generations and Health Across Generations, Gustave Roussy Institute, 114 rue Edouard Vaillant, 94805, Villejuif Cedex, France.
Douae El FatouhiCentre for Research in Epidemiology and Population Health (CESP), Inserm (Institut National de la Santé et de la Recherche Médicale) U1018, Generations and Health Across Generations, Gustave Roussy Institute, 114 rue Edouard Vaillant, 94805, Villejuif Cedex, France.
Beverley BalkauCentre for Research in Epidemiology and Population Health (CESP), Inserm (Institut National de la Santé et de la Recherche Médicale) U1018, Generations and Health Across Generations, Gustave Roussy Institute, 114 rue Edouard Vaillant, 94805, Villejuif Cedex, France.
Marie-Christine Boutron-RuaultCentre for Research in Epidemiology and Population Health (CESP), Inserm (Institut National de la Santé et de la Recherche Médicale) U1018, Generations and Health Across Generations, Gustave Roussy Institute, 114 rue Edouard Vaillant, 94805, Villejuif Cedex, France.
Fabrice BonnetService d'Endocrinologie, Groupe Hospitalier Paris St-Joseph, Paris, France.
Guy FagherazziCentre for Research in Epidemiology and Population Health (CESP), Inserm (Institut National de la Santé et de la Recherche Médicale) U1018, Generations and Health Across Generations, Gustave Roussy Institute, 114 rue Edouard Vaillant, 94805, Villejuif Cedex, France. guy.fagherazzi@gustaveroussy.fr.
Université de Versailles Saint-Quentin-en-Yvelines · FRUniversité Paris-Saclay · FRHôpital Paris Saint-Joseph · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aims/hypothesisDiet is one of the main lifestyle-related factors that can modulate the inflammatory process. Surprisingly the dietary inflammatory index (DII) has been little investigated in relation to type 2 diabetes, and the role of BMI in this relationship is not well established. We studied this association and the role of BMI in the inflammatory process in a large population-based observational study.

methodsA total of 70,991 women from the E3N (Etude Epidémiologique auprès de femmes de la Mutuelle Générale de l'Education Nationale) cohort study were followed for 20 years. Incident type 2 diabetes cases were identified using diabetes-specific questionnaires and drug reimbursement insurance databases, and 3292 incident cases were validated. The DII was derived from a validated food frequency questionnaire. Multivariable Cox regression models estimated HRs and 95% CIs between DII and incident type 2 diabetes. Interactions were tested between DII and BMI on incident type 2 diabetes and a mediation analysis of BMI was performed.

resultsHigher DII scores, corresponding to a higher anti-inflammatory potential of the diet, were associated with a lower risk of type 2 diabetes. Compared with the 1st quintile group, women from the 2nd quintile group (HR 0.85 [95% CI 0.77, 0.94]) up to the 5th quintile group (HR 0.77 [95% CI 0.69, 0.85]) had a lower risk of type 2 diabetes before adjustment for BMI. There was an interaction between DII and BMI on type 2 diabetes risk (p CONCLUSIONS/

interpretationOur findings suggest that a higher anti-inflammatory potential of the diet is associated with a lower risk of type 2 diabetes, and the association may be mediated by BMI. These results may improve our understanding of the mechanisms underlying the role of diet-related anti-inflammation in the pathogenesis of type 2 diabetes in women. Further studies are warranted to validate our results and evaluate whether the results are similar in men.

Indexed as

Body Mass IndexDietInflammationAgedDiabetes Mellitus, Type 2FemaleHumansIncidenceLife StyleMiddle AgedRiskBMI, Body mass indexCohortDiet inflammationMediation analysisPreventionRiskType 2 diabetes

Identifiers

PMID31396661
OpenAlexW2968888281

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.