ArticleClinical neuroradiology2020
Assessment of Melanin Content and its Influence on Susceptibility Contrast in Melanoma Metastases.
Article in Clinical neuroradiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Influence of metastases composition on the conspicuity of melanoma brain metastases: a comparative study of post-contrast 3D T1WI GRE versus 3D T1WI TSE black blood.La Radiologia medica · 2026Article
- Review
- Magnetic resonance imaging features and clinical course of malignant melanotic nerve sheath tumors: single institution experience over two decades.Skeletal radiology · 2023Article
- Brain metastases: the role of clinical imaging.The British journal of radiology · 2022Review
- Clinical Value of Susceptibility Weighted Imaging of Brain Metastases.Frontiers in neurology · 2020Review
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Authors and funding
10 authors.
Funding
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Abstract
purposeTo quantify the influence of melanin content on magnetic susceptibility of cerebral melanoma metastases.
methodsPatients with non-hemorrhagic metastases were included based on the absence of susceptibility blooming artifacts. Susceptibility maps were calculated from 3D gradient echo data, using Laplacian-based phase unwrapping, sophisticated harmonic artefact reduction for phase data (V-SHARP) with varying spherical kernel sizes for background field removal and the iLSQR algorithm for the inversion of phase data. Susceptibility maps were referenced to cerebrospinal fluid. Non-hemorrhagic metastases were identified on contrast-enhanced T1-weighted images and susceptibility weighted images. Metastases masks were drawn on T1-weighted post-contrast images and used to compute mean susceptibility values of each metastasis.
resultsA total of 33 non-hemorrhagic melanoma brain metastases in 20 patients were quantitatively evaluated. Metastases without and with hyperintense signal on T1-weighted images, which corresponds to the melanin content, showed median susceptibility values of -0.028 ppm and -0.020 ppm, respectively. The susceptibility differences between metastases without and with T1-weighted hyperintense signal was not statistically significant (p ≥ 0.05).
conclusionNon-hemorrhagic cerebral melanoma metastases showed weak diamagnetic susceptibility values and susceptibility did not significantly correlate to T1-weighted signals. Therefore, melanin does not seem to be a major contributor to susceptibility in cerebral melanoma metastases.
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