ArticleNucleic acids research2019
Remodeling of the Caenorhabditis elegans non-coding RNA transcriptome by heat shock.
Article in Nucleic acids research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 39 citations in OpenAlex.
- Life-History, Stress-Resistance, and Transcriptomic Variation Among a MexicanEcology and evolution · 2026Article
- Computational Analysis of Telomerase RNA Evolution inNon-coding RNA · 2026Article
- Transcriptomic and chromatin accessibility profiling unveils new regulators of heat hormesis in Caenorhabditis elegans.PLoS biology · 2026Article
- Heat-induced transcriptional activation of LTR retrotransposons in the regenerative flatworm Macrostomum lignano.Mobile DNA · 2025Article
- The mex-3 3' untranslated region is essential for reproduction during temperature stress.Development (Cambridge, England) · 2025Article
- Transposable Elements Drive Regulatory and Functional Innovation of F-box Genes.Molecular biology and evolution · 2025Article
- Widespread destabilization ofRNA (New York, N.Y.) · 2024Article
- Full-length direct RNA sequencing reveals extensive remodeling of RNA expression, processing and modification in aging Caenorhabditis elegans.Nucleic acids research · 2024Article
- Full-length direct RNA sequencing reveals extensive remodeling of RNA expression, processing and modification in agingbioRxiv : the preprint server for biology · 2024Article
- An Intricate Network Involving the Argonaute ALG-1 Modulates Organismal Resistance to Oxidative Stress.Nature communications · 2024Article
- Recent advances in understanding microRNA function and regulation in C. elegans.Seminars in cell & developmental biology · 2024Review
- Inheritance of Stress Responses via Small Non-Coding RNAs in Invertebrates and Mammals.Epigenomes · 2023Review
- Expression, not sequence, distinguishes miR-238 from its miR-239ab sister miRNAs in promoting longevity in Caenorhabditis elegans.PLoS genetics · 2023Article
- MicroRNAs in Age-Related Proteostasis and Stress Responses.Non-coding RNA · 2023Review
- Article
- The Thermal Stress Coping Network of the NematodeInternational journal of molecular sciences · 2022Review
- Nuclear and cytoplasmic poly(A) binding proteins (PABPs) favor distinct transcripts and isoforms.Nucleic acids research · 2022Article
- Role of Nuclear Non-Canonical Nucleic Acid Structures in Organismal Development and Adaptation to Stress Conditions.Frontiers in genetics · 2022Review
- Region-specific H3K9me3 gain in aged somatic tissues in Caenorhabditis elegans.PLoS genetics · 2021Article
- Recovery from heat shock requires the microRNA pathway in Caenorhabditis elegans.PLoS genetics · 2021Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Elevated temperatures activate a heat shock response (HSR) to protect cells from the pathological effects of protein mis-folding, cellular mis-organization, organelle dysfunction and altered membrane fluidity. This response includes activation of the conserved transcription factor heat shock factor 1 (HSF-1), which binds heat shock elements (HSEs) in the promoters of genes induced by heat shock (HS). The upregulation of protein-coding genes (PCGs), such as heat shock proteins and cytoskeletal regulators, is critical for cellular survival during elevated temperatures. While the transcriptional response of PCGs to HS has been comprehensively analyzed in a variety of organisms, the effect of this stress on the expression of non-coding RNAs (ncRNAs) has not been systematically examined. Here we show that in Caenorhabditis elegans HS induces up- and downregulation of specific ncRNAs from multiple classes, including miRNA, piRNA, lincRNA, pseudogene and repeat elements. Moreover, some ncRNA genes appear to be direct targets of the HSR, as they contain HSF-1 bound HSEs in their promoters and their expression is regulated by this factor during HS. These results demonstrate that multiple ncRNA genes respond to HS, some as direct HSF-1 targets, providing new candidates that may contribute to organismal survival during this stress.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.