Evidence map›Paper›PMID 31396587›Full record

ArticleACS applied bio materials2018

Water-Dispersible Bismuth-Organic Materials with Computed Tomography Contrast Properties.

Guoxian Zhang, Pratap C Naha, Prabhat Gautam, David P Cormode, Julian M W Chan

Abstract read
In one paragraph

Article in ACS applied bio materials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Nanomaterial-based contrast agents.Nature reviews. Methods primers · 2023
    Article
  3. Nanoparticle contrast agents for X-ray imaging applications.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2020
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Guoxian ZhangDepartment of Chemistry and Biomolecular Sciences, University of Ottawa, 10 Marie Curie Pvt., Ottawa, Ontario K1N 6N5, Canada.
Pratap C NahaDepartment of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.ORCID 0000-0002-3173-7879
Prabhat GautamDepartment of Chemistry and Biomolecular Sciences, University of Ottawa, 10 Marie Curie Pvt., Ottawa, Ontario K1N 6N5, Canada.
David P CormodeDepartment of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.ORCID 0000-0002-8391-9500
Julian M W ChanDepartment of Chemistry and Biomolecular Sciences, University of Ottawa, 10 Marie Curie Pvt., Ottawa, Ontario K1N 6N5, Canada.ORCID 0000-0002-2734-6496

Funding

Biodegradable polymetal nanoparticle CT contrast agents for vascular imagingR01HL131557 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CORMODE, DAVID PETER · 2016 to 2020
$2.0M
NHLBI NIH HHS R01 HL131557
6 · The paper itself

Abstract

Two bismuth-organic network polymers were synthesized by means of a one-step polycondensation reaction between an aromatic dithiol/trithiol and triphenylbismuth. The materials were characterized by solid-state UV-vis spectroscopy, Raman spectroscopy, scanning electron microscopy, energy dispersive X-ray spectroscopy, powder X-ray diffraction, elemental microanalysis, and thermogravimetric analysis. Uniform dispersion of the hydrophobic and water-insoluble bismuth-containing polymers in aqueous media was achieved by the addition of 2 kDa poly(ethylene glycol) methyl ether thiol. This enabled quantitative phantom imaging experiments on a clinical computed tomography (CT) scanner, which showed that the coordination polymers possessed strong CT contrast properties. The observed X-ray attenuation properties of each coordination polymer were correlated with its bismuth payload. The X-ray opacity, thermal and chemical stabilities, and aqueous dispersibility of this novel class of bismuth-organic materials make them potentially useful as biomedical CT contrast agents and radiopaque materials.

Indexed as

bismuth thiolatescoordination polymersCT contrast agentsorganic–inorganic hybrid materialsradiopaque polymersX-ray contrast

Identifiers

PMID31396587
PMCPMC6687070

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.