ArticleCommunications biology2019
Bcl11b controls odorant receptor class choice in mice.
Article in Communications biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- A spatial code governs olfactory receptor choice and aligns sensory maps in the nose and brain.Cell · 2026Article
- Non-uniform endogenous regeneration of olfactory sensory neuron axons across the mouse olfactory bulb.Scientific reports · 2026Article
- Foxg1 Defines Ventrolateral Zonal Identity by Sustaining Neurogenic Progenitor Potential in the Olfactory Epithelium.Genes to cells : devoted to molecular & cellular mechanisms · 2026Article
- An epigenetic repressor TRIM66 dictates monogenic olfactory receptor expression, neural activity, and olfactory behavior.Nature communications · 2025Article
- Foxg1 and Retinoic Acid Signaling Regulate Zonal Patterning in the Developing Olfactory Epithelium.Development, growth & differentiation · 2025Article
- A common mechanism of singular gene choice is revealed by broadly expressed odorant receptor transgenes within the olfactory epithelium.Cell reports · 2025Article
- Genomic snowflakes: how the uniqueness of DNA folding allows us to smell the chemical universe.Current opinion in genetics & development · 2025Review
- Determinants of odorant receptor transcription and gene choice.Chemical senses · 2025Review
- Establishment and maintenance of random monoallelic expression.Development (Cambridge, England) · 2024Review
- Epigenetic programming of stochastic olfactory receptor choice.Genesis (New York, N.Y. : 2000) · 2024Review
- Illuminating the terminal nerve: Uncovering the link between GnRH-1 neuron and olfactory development.The Journal of comparative neurology · 2024Article
- Article
- Molecular Evidence for Olfactory Neuroblastoma as a Tumor of Malignant Globose Basal Cells.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2023Article
- MRI tractography reveals the human olfactory nerve map connecting the olfactory epithelium and olfactory bulb.Communications biology · 2022Article
- Olfactory receptor choice: a case study for gene regulation in a multi-enhancer system.Current opinion in genetics & development · 2022Review
- Sleep deprivation induces delayed regeneration of olfactory sensory neurons following injury.Frontiers in neuroscience · 2022Article
- Olfactory expression of trace amine-associated receptors requires cooperative cis-acting enhancers.Nature communications · 2021Article
- Bcl11b is required for proper odorant receptor expression in the mouse septal organ.Cell and tissue research · 2021Article
- A class I odorant receptor enhancer shares a functional motif with class II enhancers.Scientific reports · 2021Article
- Maturation of the Olfactory Sensory Neuron and Its Cilia.Chemical senses · 2020Review
Corrections and comments
- Erratum issued
Authors and funding
13 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Each olfactory sensory neuron (OSN) expresses a single odorant receptor (OR) gene from the class I or class II repertoire in mice. The mechanisms that regulate OR class choice in OSNs remain unknown. Here, we show that the transcription factor Bcl11b determines the OR class to be expressed in OSNs. Both loss- and gain-of-function analyses demonstrate that class I is a default fate of OSNs and that Bcl11b dictates a class II OR choice by suppressing the effect of the J-element, a class I-OR enhancer. We further demonstrate that OSN-specific genetic manipulations of Bcl11b bias the OR class choice, generating mice with "class I-dominant" and "class II-dominant" noses, which display contrasting innate olfactory behaviors to two distinct aversive odorants. Overall, these findings reveal a unique transcriptional mechanism mediating a binary switch for OR class choice that is crucial to both the anatomical and functional organization of the olfactory system.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.