Evidence map›Paper›PMID 31396573›Full record

ArticleCommunications biology2019

High-resolution crystal structure of arthropod Eiger TNF suggests a mode of receptor engagement and altered surface charge within endosomes.

Mattia Bertinelli, Guido C Paesen, Jonathan M Grimes, Max Renner

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Mattia Bertinelli1Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, 10 Roosevelt Drive, Oxford, OX3 7BN UK.ORCID 0000-0002-6336-6769
Guido C Paesen1Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, 10 Roosevelt Drive, Oxford, OX3 7BN UK.
Jonathan M Grimes1Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, 10 Roosevelt Drive, Oxford, OX3 7BN UK.ORCID 0000-0001-9698-0389
Max Renner1Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, 10 Roosevelt Drive, Oxford, OX3 7BN UK.
Centre for Human Genetics · GB

Funding

Wellcome Trust 203141/Z/16/ZWellcome Trust 204703/Z/16/Z
6 · The paper itself

Abstract

The tumour necrosis factor alpha (TNFα) superfamily of proteins are critical in numerous biological processes, such as in development and immunity. Eiger is the sole TNFα member described in arthropods such as in the important model organism

Indexed as

AnimalsCrystallography, X-RayEndosomesInsect ProteinsMolecular Dynamics SimulationProtein ConformationReceptors, Tumor Necrosis FactorSignal TransductionSpodopteraStructure-Activity RelationshipSurface PropertiesTumor Necrosis Factor-alphaInsect ProteinsReceptors, Tumor Necrosis FactorTumor Necrosis Factor-alphaApoptosisCell signallingX-ray crystallography

Identifiers

PMID31396573
PMCPMC6684607
OpenAlexW2966874746

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.