ArticlePeerJ2019
A 3-mRNA-based prognostic signature of survival in oral squamous cell carcinoma.
Article in PeerJ, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 58 citations in OpenAlex.
- Unveiling the Mysteries of CLEC3B: Physiological Roles, Pathological Impacts, and Research Gaps.Cells · 2026Review
- Deep visual detection system for oral squamous cell carcinoma.Scientific reports · 2026Article
- A Narrative Review of Prognostic Gene Signatures in Oral Squamous Cell Carcinoma Using LASSO Cox Regression.Biomedicines · 2025Review
- CRISPR/Cas9-based discovery of ccRCC therapeutic opportunities through molecular mechanism and immune microenvironment analysis.Frontiers in immunology · 2025Article
- Pairwise analysis of gene expression for oral squamous cell carcinoma via a large-scale transcriptome integration.Journal of cellular and molecular medicine · 2024Article
- A Prognostic Model Based on Cisplatin-Resistance Related Genes in Oral Squamous Cell Carcinoma.Oral health & preventive dentistry · 2024Article
- Article
- Prognosis-related molecular subtyping in head and neck squamous cell carcinoma patients based on glycolytic/cholesterogenic gene data.Cancer cell international · 2023Article
- Systematic establishment and verification of an epithelial-mesenchymal transition gene signature for predicting prognosis of oral squamous cell carcinoma.Frontiers in genetics · 2023Article
- Gene signature predicting recurrence in oral squamous cell carcinoma is characterized by increased oxidative phosphorylation.Molecular oncology · 2023Article
- Identification and validation of potential novel biomarkers for oral squamous cell carcinoma.Bioengineered · 2021Article
- Characteristic of molecular subtypes in lung adenocarcinoma based on m6A RNA methylation modification and immune microenvironment.BMC cancer · 2021Article
- Application of the Interaction between Tissue Immunohistochemistry Staining and Clinicopathological Factors for Evaluating the Risk of Oral Cancer Progression by Hierarchical Clustering Analysis: A Case-Control Study in a Taiwanese Population.Diagnostics (Basel, Switzerland) · 2021Article
- Clinical effect of robot-assisted radical cystectomy in bladder cancer.American journal of translational research · 2021Article
- Expression Characteristics and Significant Prognostic Values of PGK1 in Breast Cancer.Frontiers in molecular biosciences · 2021Article
- Therapeutic potential of targetingAging · 2020Article
- Prognostic value and immune cell infiltration of hypoxic phenotype-related gene signatures in glioblastoma microenvironment.Journal of cellular and molecular medicine · 2020Article
- Development and validation of a fourteen- innate immunity-related gene pairs signature for predicting prognosis head and neck squamous cell carcinoma.BMC cancer · 2020Article
- Potential five-mRNA signature model for the prediction of prognosis in patients with papillary thyroid carcinoma.Oncology letters · 2020Article
- CLEC3B as a potential diagnostic and prognostic biomarker in lung cancer and association with the immune microenvironment.Cancer cell international · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOral squamous cell carcinoma (OSCC) is the most common type of head and neck squamous cell carcinoma with an unsatisfactory prognosis. The aim of this study was to identify potential prognostic mRNA biomarkers of OSCC based on analysis of The Cancer Genome Atlas (TCGA).
methodsExpression profiles and clinical data of OSCC patients were collected from TCGA database. Univariate Cox analysis and the least absolute shrinkage and selection operator Cox (LASSO Cox) regression were used to primarily screen prognostic biomarkers. Then multivariate Cox analysis was performed to build a prognostic model based on the selected prognostic mRNAs. Nomograms were generated to predict the individual's overall survival at 3 and 5 years. The model performance was assessed by the time-dependent receiver operating characteristic (ROC) curve and calibration plot in both training cohort and validation cohort (GSE41613 from NCBI GEO databases). In addition, machine learning was used to assess the importance of risk factors of OSCC. Finally, in order to explore the potential mechanisms of OSCC, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis was completed.
resultsThree mRNAs (
conclusionA 3-mRNA signature (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.