ArticleNPJ systems biology and applications2019
Genetic signature related to heme-hemoglobin metabolism pathway in sepsis secondary to pneumonia.
Article in NPJ systems biology and applications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- Biologic Mechanisms Underlying the Heterogeneous Response to Tight Glycemic Control among Differentially Inflamed Patients in the HALF-PINT Trial.American journal of respiratory and critical care medicine · 2025Trial
- Association of gender and main comorbidities with expression of lncRNAs and mRNAs in COVID-19 patients.Journal, genetic engineering & biotechnology · 2026Article
- The role of four ERS-related key genes in sepsis induced organ dysfunction and the forewarning model construction.BMC medical informatics and decision making · 2025Article
- Early Prediction of Septic Shock in Emergency Department Using Serum Metabolites.Journal of the American Society for Mass Spectrometry · 2025Article
- Innovative nomogram for predictive risk stratification of aspiration pneumonia in post-stroke dysphagia patients.Frontiers in neurology · 2025Article
- Longitudinal transcriptomic analysis reveals persistent enrichment of iron homeostasis and erythrocyte function pathways in severe COVID-19 ARDS.Frontiers in immunology · 2024Article
- PBMCs gene expression predicts liver fibrosis regression after successful HCV therapy in HIV/HCV-coinfected patients.Frontiers in pharmacology · 2024Article
- Predicting severity in COVID-19 disease using sepsis blood gene expression signatures.Scientific reports · 2023Article
- Prospective study and validation of early warning marker discovery based on integrating multi-omics analysis in severe burn patients with sepsis.Burns & trauma · 2023Article
- Severe COVID-19 and non-COVID-19 severe sepsis converge transcriptionally after a week in the intensive care unit, indicating common disease mechanisms.Frontiers in immunology · 2023Observational
- Global characterization of megakaryocytes in bone marrow, peripheral blood, and cord blood by single-cell RNA sequencing.Cancer gene therapy · 2022Article
- Genome-Wide mRNA Expression Analysis of Acute Psychological Stress Responses.MEDICC review · 2022Article
- Metabolomics Signatures of SARS-CoV-2 Infection.Advances in experimental medicine and biology · 2022Review
- A Bioinformatics Study of Ropivacaine plus Dexamethasone Prolonging the Duration of Nerve Block.Computational intelligence and neuroscience · 2022Article
- Integrative Systems Biology Approaches to Identify Potential Biomarkers and Pathways of Cervical Cancer.Journal of personalized medicine · 2021Article
- Combined Transcriptome and Proteome Leukocyte's Profiling Reveals Up-Regulated Module of Genes/Proteins Related to Low Density Neutrophils and Impaired Transcription and Translation Processes in Clinical Sepsis.Frontiers in immunology · 2021Article
- The Role of Hemoglobin Subunit Delta in the Immunopathy of Multiple Sclerosis: Mitochondria Matters.Frontiers in immunology · 2021Article
- Proteomics and Machine Learning Approaches Reveal a Set of Prognostic Markers for COVID-19 Severity With Drug Repurposing Potential.Frontiers in physiology · 2021Article
- Noncoding RNAs implication in cardiovascular diseases in the COVID-19 era.Journal of translational medicine · 2020Review
- Interplay of Heme with Macrophages in Homeostasis and Inflammation.International journal of molecular sciences · 2020Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated inflammatory response to pathogens. Bioinformatics and transcriptomics studies contribute to get a better understanding of the pathogenesis of sepsis. These studies revealed differentially expressed genes (DEGs) in sepsis involved in several pathways. Here we investigated the gene expression profiles of blood leukocytes using three microarray datasets of sepsis secondary to pneumonia, focusing on the heme/hemoglobin metabolism pathway. We demonstrate that the heme/hemoglobin metabolism pathway was found to be enriched in these three cohorts with four common genes (
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.