ArticleAmerican journal of translational research2019
Cytoplasmic upregulation of Cyto c and AIF serve as biomarkers of mechanical asphyxia death.
Article in American journal of translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Combined machine learning identification and experimental validation of NDUFS8 and SUCLG1 as potential biomarkers for mechanical asphyxia.Frontiers in medicine · 2026Article
- Post Mortem Molecular Biomarkers of Asphyxia: A Literature Review.International journal of molecular sciences · 2024Review
- Use of Raman spectroscopy to study rat lung tissues for distinguishing asphyxia from sudden cardiac death.RSC advances · 2024Article
- Article
- ER stress-related protein, CHOP, may serve as a biomarker of mechanical asphyxia: a primary study.International journal of legal medicine · 2022Article
- Metabolomics improves the histopathological diagnosis of asphyxial deaths: an animal proof-of-concept model.Scientific reports · 2021Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The certification of death due to mechanical asphyxia has been a complex problem in some cases. The use of protein expression to identify mechanical asphyxia death has recently attracted attention. Asphyxia creates an extremely hypoxic environment for cells, which should reactivate the mitochondria in the cells. Cyto c and AIF, located in the mitochondria, are transferred to the cytoplasm under hypoxia to trigger the apoptotic process. Based this phenomenon, we designed the animal asphyxia model and cell hypoxia model to examine whether Cyto c and AIF are expressed in the cytoplasm, and we used human samples to verify the results. We found that the two proteins were detectably expressed in the cytoplasm of mechanical asphyxia groups and were hardly detected in the cytoplasm of other groups. This is a promising finding that may shed light on the precise mechanisms associated with mechanical asphyxia.
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31396361PMC6684934W2990544992What OpenQuestion holds
Registered trials
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