ArticleAmerican journal of translational research2019
Swimming prevents nonalcoholic fatty liver disease by reducing migration inhibitory factor through Akt suppression and autophagy activation.
Article in American journal of translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Therapeutic Effects of microRNAs on Nonalcoholic Fatty Liver Disease (NAFLD) and Nonalcoholic Steatohepatitis (NASH): A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2023Pooled it
- Targeting necroptosis: how does exercise protect against metabolic dysfunction-associated fatty liver disease?Frontiers in physiology · 2026Review
- Exercise-driven cellular autophagy: A bridge to systematic wellness.Journal of advanced research · 2025Review
- Autolysosomal Dysfunction in Obesity-induced Metabolic Inflammation and Related Disorders.Current obesity reports · 2025Review
- Mechanisms underpinning the effect of exercise on the non-alcoholic fatty liver disease: review.EXCLI journal · 2025Review
- Autophagy in metabolic disease and ageing.Nature reviews. Endocrinology · 2021Review
- The interplay of microRNAs and transcription factors in autophagy regulation in nonalcoholic fatty liver disease.Experimental & molecular medicine · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Physical inactivity is an important contributor to obesity and fat accumulation in tissues. Critical complications of obesity include type II diabetes and nonalcoholic fatty liver disease (NAFLD). Exercise has been reported to exert ameliorating effects on obesity and NAFLD. However, the underlying mechanism is not fully understood. We showed the increase of microRNA-451 (miR-451) and decrease of macrophage migration inhibitory factor (MIF) in liver, after swim training in high fat diet (HFD) mice. MIF expression was regulated by miR-451. HFD intake caused the increase of body weights in WT and MIF knockout (KO) mice. In addition, HFD-induced liver anomalies were associated with Akt activation and autophagy suppression, which were reversed by MIF KO. In hepatocytes from HFD WT and MIF KO mice, autophagy was inhibited by exogenous rmMIF through Akt activation. Meanwhile, miR-451 antagonized the regulation of MIF on Akt signaling and autophagy. Taken together, these results indicate that MIF was decreased in liver of HFD mice due to physical exercise, and might prevent hepatic steatosis by suppressing Akt signaling and promoting autophagy.
Indexed as
Identifiers
31396337PMC6684928W2980686715What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.