ArticleAmerican journal of translational research2019
miRNA-574-3p inhibits metastasis and chemoresistance of epithelial ovarian cancer (EOC) by negatively regulating epidermal growth factor receptor (EGFR).
Article in American journal of translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 20 citations in OpenAlex.
- Subtype-specific mechanisms of lipid metabolism in gynecological malignancies and novel targeted intervention strategies (Review).Oncology letters · 2026Review
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- A comprehensive review on RNA interference-mediated targeting of interleukins and its potential therapeutic implications in colon cancer.3 Biotech · 2023Review
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- Interleukin-18 promotes the antitumor ability of natural killer cells in colorectal cancer via the miR-574-3p/TGF-β1 axis.Bioengineered · 2021Article
- LINC00997/MicroRNA 574-3p/CUL2 Promotes Cervical Cancer Development via Mitogen-Activated Protein Kinase Signaling.Molecular and cellular biology · 2021Article
- Approaches Toward Targeting Matrix Metalloproteases for Prognosis and Therapies in Gynecological Cancer: MicroRNAs as a Molecular Driver.Frontiers in oncology · 2021Review
- Common miRNAs, candidate genes and their interaction network across four subtypes of epithelial ovarian cancer.Bioinformation · 2021Article
- The Role of microRNAs in Epithelial Ovarian Cancer Metastasis.International journal of molecular sciences · 2020Review
- MicroRNA-574-3p inhibits the malignant behavior of liver cancer cells by targeting ADAM28.Oncology letters · 2020Article
- circCELSR1 (hsa_circ_0063809) Contributes to Paclitaxel Resistance of Ovarian Cancer Cells by Regulating FOXR2 Expression via miR-1252.Molecular therapy. Nucleic acids · 2020Article
- Roles of microRNAs in Ovarian Cancer Tumorigenesis: Two Decades Later, What Have We Learned?Frontiers in oncology · 2020Review
- ZEB1-AS1/miR-133a-3p/LPAR3/EGFR axis promotes the progression of thyroid cancer by regulating PI3K/AKT/mTOR pathway.Cancer cell international · 2020Article
- An Anti-inflammatory microRNA Signature Distinguishes Group 3 Innate Lymphoid Cells From Natural Killer Cells in Human Decidua.Frontiers in immunology · 2020Article
- MiR-338-3p Enhances Ovarian Cancer Cell Sensitivity to Cisplatin by Downregulating WNT2B.Yonsei medical journal · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis current study explored the role of miRNA-574-3p and the related molecular mechanisms in epithelial ovarian cancer (EOC).
methodsTissues of ovarian cancer patients were applied to explore the correlation between miRNA-574-3p and EOC. The role of miRNA-574-3p in migration, invasion and chemoresistance of EOC cells was evaluated by overexpression and suppression of miRNA-574-3p in SKOV3 and CAOV3 cells. For the sake of exploring how miRNA-574-3p regulated tumor migration, invasion and chemoresistance of EOC cells, we detected several related molecular expressions and activities of signaling pathways.
resultsOverexpression of epidermal growth factor receptor (EGFR) was correlated with downregulation of miR-574-3p in EOC tissues. Overexpression of miRNA-574-3p in EOC cells led to inhibition of cell migration as well as invasion, and it significantly promoted the sensitivities of EOC cells to paclitaxel and cisplatin. Molecular experiments showed miR-574-3p inhibited activation of AKT, FAK and c-Src, as well as MMP-9 expression via targeting EGFR.
conclusionTaken together, these data demonstrated that miRNA-574-3p inhibits both tumor metastasis and chemoresistance in EOC via targeting EGFR. Thus, targeting miRNA-574-3p may become a potential molecular method for EOC.
Indexed as
Identifiers
31396325PMC6684900W2982567630What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.