Evidence map›Paper›PMID 31396224›Full record

ArticleFrontiers in immunology2019

Divergent Peptide Presentations of HLA-A

Shiyan Zhu, Kefang Liu, Yan Chai, Yanan Wu, Dan Lu, Wenling Xiao, Hao Cheng, Yingze Zhao, Chunming Ding, Jianxin Lyu and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. HLA micropolymorphisms confine neoantigen conformational adaptability and guide T cell receptor selectivity.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  6. Review
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  10. Cross-species recognition of SARS-CoV-2 to bat ACE2.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Shiyan ZhuSchool of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, China.
Kefang LiuNHC Key Laboratory of Medical Virology and Viral Diseases, Chinese Center for Disease Control and Prevention, National Institute for Viral Disease Control and Prevention, Beijing, China.
Yan ChaiCAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Yanan WuSchool of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, China.
Dan LuNHC Key Laboratory of Medical Virology and Viral Diseases, Chinese Center for Disease Control and Prevention, National Institute for Viral Disease Control and Prevention, Beijing, China.
Wenling XiaoSchool of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, China.
Hao ChengBeijing Institutes of Life Science, University of Chinese Academy of Sciences, Beijing, China.
Yingze ZhaoNHC Key Laboratory of Medical Virology and Viral Diseases, Chinese Center for Disease Control and Prevention, National Institute for Viral Disease Control and Prevention, Beijing, China.
Chunming DingSchool of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, China.
Jianxin LyuSchool of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, China.
Yongliang LouSchool of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, China.
George F GaoSchool of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, China.
William J LiuSchool of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, China.
National Institute for Viral Disease Control and Prevention · CNWenzhou Medical University · CNHangzhou Medical College · CNInstitute of Microbiology · CNUniversity of Chinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human leukocyte antigen (HLA) alleles have a high degree of polymorphism, which determines their peptide-binding motifs and subsequent T-cell receptor recognition. The simplest way to understand the cross-presentation of peptides by different alleles is to classify these alleles into supertypes. A1 and A3 HLA supertypes are widely distributed in humans. However, direct structural and functional evidence for peptide presentation features of key alleles (e.g., HLA-A

Indexed as

Antigen PresentationCross-PrimingEpitopes, T-LymphocyteHIVHLA-A AntigensHumansLymphocyte ActivationMycobacterium tuberculosisOrthomyxoviridaePeptidesEpitopes, T-LymphocyteHLA-A*30 antigenHLA-A AntigensPeptidescross-presentationHLA-A3HLA superfamilyhuman immunodeficiency virus (HIV)influenza virusmajor histocompatibility complex (MHC)Mycobacterium tuberculosisT-cell

Identifiers

PMID31396224
PMCPMC6664060
OpenAlexW2961879920

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.