Evidence map›Paper›PMID 31396221›Full record

ArticleFrontiers in immunology2019

Diminished HIV Infection of Target CD4+ T Cells in a Toll-Like Receptor 4 Stimulated

Ross Cromarty, Alex Sigal, Lenine J P Liebenberg, Lyle R McKinnon, Salim S Abdool Karim, Jo-Ann S Passmore, Derseree Archary

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. The CD8Microbiology and molecular biology reviews : MMBR · 2021
    Review
  4. Review
  5. Frontiers in cell and developmental biology · 2021
    Article
  6. Betamethasone induces potent immunosuppression and reduces HIV infection in a PBMC in vitro model.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2021
    Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 4 countries.

Ross CromartyCentre for the AIDS Programme of Research in South Africa, Nelson Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
Alex SigalAfrica Health Research Institute, University of KwaZulu-Natal, Durban, South Africa.
Lenine J P LiebenbergCentre for the AIDS Programme of Research in South Africa, Nelson Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
Lyle R McKinnonCentre for the AIDS Programme of Research in South Africa, Nelson Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
Salim S Abdool KarimCentre for the AIDS Programme of Research in South Africa, Nelson Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
Jo-Ann S PassmoreCentre for the AIDS Programme of Research in South Africa, Nelson Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
Derseree ArcharyCentre for the AIDS Programme of Research in South Africa, Nelson Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
University of KwaZulu-Natal · ZACentre for the AIDS Programme of Research in South Africa · ZAAfrica Health Research Institute · ZA

Funding

Inflammation and HIV risk: understanding partial Tenofovir efficacy in CAPRISA004R01AI111936 · NIAID · CENTRE/AIDS PROGRAMME/RES/SOUTH AFRICA · PI PASSMORE, JO-ANN SHELLEY · 2014 to 2017
$2.1M
NIAID NIH HHS R01 AI111936
6 · The paper itself

Abstract

Genital inflammation is associated with increased HIV acquisition risk. Induction of an inflammatory response can occur through the recognition of pathogenic or commensal microbes by Toll-like receptors (TLRs) on various immune cells. We used a

Indexed as

CD4-Positive T-LymphocytesCells, CulturedHIV InfectionsHumansLymphocyte ActivationToll-Like Receptor 4TLR4 protein, humanToll-Like Receptor 4cytokinesHIVimmune activationinflammationinnate antiviral immunityToll-like receptors

Identifiers

PMID31396221
PMCPMC6664077
OpenAlexW2957795115

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.