Evidence map›Paper›PMID 31396217›Full record

ArticleFrontiers in immunology2019

Chronic Ly49H Receptor Engagement

Phillip N Key, Joe Germino, Liping Yang, Sytse J Piersma, Sandeep K Tripathy

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. The Role of Calcium Signaling in Melanoma.International journal of molecular sciences · 2022
    Review
  3. NK Cell Hyporesponsiveness: More Is Not Always Better.International journal of molecular sciences · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Phillip N KeyGastroenterology Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States.
Joe GerminoGastroenterology Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States.
Liping YangRheumatology Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States.
Sytse J PiersmaRheumatology Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States.
Sandeep K TripathyGastroenterology Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States.
Washington University in St. Louis · US

Funding

Washington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Nicholas O. Davidson · 2000 to 2026
$30.8M
MECHANISMS OF NATURAL KILLER CELL TOLERANCER01AI089870 · NIAID · WASHINGTON UNIVERSITY · PI TRIPATHY, SANDEEP KUMAR · 2011 to 2014
$1.5M
NIAID NIH HHS R01 AI089870NIDDK NIH HHS P30 DK052574
6 · The paper itself

Abstract

Natural killer (NK) cells play an important role in the innate immune response. The summation of activation and inhibitory signals delivered through cell surface membrane receptors determines NK cell function. However, the continuous engagement of an activating receptor on NK cells appears to render the cells hyporesponsive to stimulation through other unrelated activating receptors. The mechanism by which this takes place remains unclear. Herein we demonstrate that continuous

Indexed as

AnimalsImmune ToleranceKiller Cells, NaturalLymphocyte ActivationMiceMice, TransgenicNK Cell Lectin-Like Receptor Subfamily ASignal TransductionKlra8 protein, mouseNK Cell Lectin-Like Receptor Subfamily Aactivating receptorITAMLy49Hm157NK cellsignal transductiontolerance

Identifiers

PMID31396217
PMCPMC6664057
OpenAlexW2960595906

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.