Evidence map›Paper›PMID 31396216›Full record

ArticleFrontiers in immunology2019

Phenotypic Expansion in Nasu-Hakola Disease: Immunological Findings in Three Patients and Proposal of a Unifying Pathogenic Hypothesis.

Edoardo Errichiello, Efthimios Dardiotis, Fiorenza Mannino, Juha Paloneva, Teresa Mattina, Orsetta Zuffardi

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Neuroglial Pathophysiology of Leukodystrophies.Advances in neurobiology · 2025
    Review
  2. Article
  3. Article
  4. Natural killer cells in the central nervous system.Cell communication and signaling : CCS · 2023
    Review
  5. Review
  6. The Primary Microglial Leukodystrophies: A Review.International journal of molecular sciences · 2022
    Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Edoardo ErrichielloUnit of Medical Genetics, Department of Molecular Medicine, University of Pavia, Pavia, Italy.
Efthimios DardiotisDepartment of Neurology, University Hospital of Larissa, University of Thessaly, Larissa, Greece.
Fiorenza ManninoDepartment of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
Juha PalonevaDepartment of Surgery, Central Finland Hospital, Jyväskylä, Finland.
Teresa MattinaDepartment of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
Orsetta ZuffardiUnit of Medical Genetics, Department of Molecular Medicine, University of Pavia, Pavia, Italy.
University of Catania · ITUniversity of Pavia · ITCentral Finland Health Care District · FIUniversity Hospital of Larissa · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nasu-Hakola disease (NHD) is a rare autosomal recessive disorder characterized by progressive presenile dementia and bone cysts, caused by variants in either

Indexed as

Adaptor Proteins, Signal TransducingAdultFemaleHumansKiller Cells, NaturalLipodystrophyMembrane GlycoproteinsMembrane ProteinsMutationNeuroimmunomodulationOsteochondrodysplasiasPedigreePhenotypeReceptors, ImmunologicSubacute Sclerosing PanencephalitisAdaptor Proteins, Signal TransducingMembrane GlycoproteinsMembrane ProteinsReceptors, ImmunologicTREM2 protein, humanTYROBP protein, humanautoantibodiesbone cystsmicrogliaNasu-Hakola disease (NHD)neurodegenerationNK cellsTREM2TYROBP

Identifiers

PMID31396216
PMCPMC6664049
OpenAlexW2954356003

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.