ReviewFrontiers in endocrinology2019
Postnatal Testicular Activity in Healthy Boys and Boys With Cryptorchidism.
Review in Frontiers in endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Delayed Presentation of Classic Bladder Exstrophy Associated With Epispadias and Bilateral Non-Scrotal Testes in an 11-Year-Old Afghan Boy: A Case Report.Clinical case reports · 2026Article
- Seminal Plasma Metabolomic Profiling Reveals Key Metabolic Signatures Linked to Spermatogenic Potential in Non-Obstructive Azoospermia with Cryptorchidism.Metabolites · 2026Article
- Modified shehata surgery vs. laparoscopic One-stage orchiopexy for intra-abdominal cryptorchidism: a comparative retrospective study.Frontiers in surgery · 2026Article
- Night work during pregnancy and risk of cryptorchidism among male offspring: A Danish nationwide register-based cohort study.Andrology · 2026Article
- Morphological identification and distribution comparison of telocytes in pituitary gland between normal and cryptorchid yaks.BMC veterinary research · 2024Article
- Development of external genitalia during mini-puberty: is it related to somatic growth or reproductive hormones?European journal of pediatrics · 2024Article
- Anti-Müllerian hormone, testicular descent and cryptorchidism.Frontiers in endocrinology · 2024Review
- Article
- Biometrical and histomorphometrical changes of testis in the dynamics of postnatal ontogenesis from birth to puberty of Black Bengal goat.Journal of advanced veterinary and animal research · 2023Article
- Steroid receptors in the testis: implications in the physiology of prenatal and postnatal development and translation to clinical application.Histology and histopathology · 2023Review
- Clinical aspects of histological and hormonal parameters in boys with cryptorchidism: Thesis for PhD degree.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2022Article
- Serum Testosterone Levels in 3-Month-Old Boys Predict Their Semen Quality as Young Adults.The Journal of clinical endocrinology and metabolism · 2022Article
- Reversible hypogonadotropic hypogonadism in men with the fertile eunuch/Pasqualini syndrome: A single-center natural history study.Frontiers in endocrinology · 2022Article
- Recent advances in understanding and managing Kallmann syndrome.Faculty reviews · 2021Review
- Comparison of diagnostic and treatment guidelines for undescended testis.Clinical and experimental pediatrics · 2020Article
- Premature Adrenarche in Children with Prader-Willi Syndrome Treated with Recombinant Human Growth Hormone Seems to Not Influence the Course of Central Puberty and the Efficacy and Safety of the Therapy.Life (Basel, Switzerland) · 2020Article
- Minipuberty in Klinefelter syndrome: Current status and future directions.American journal of medical genetics. Part C, Seminars in medical genetics · 2020Review
- The relationship between vascular endothelial growth factor and spermatogenesis disturbance in an experimentally-induced unilateral cryptorchidism murine model.Molecular biology reports · 2020Article
- Ontogeny of Hypothalamus-Pituitary Gonadal Axis and Minipuberty: An Ongoing Debate?Frontiers in endocrinology · 2020Review
- Review
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cryptorchidism, or undescended testis, is a well-known risk factor for testicular cancer and impaired semen quality in adulthood, conditions which have their origins in early fetal and postnatal life. In human pregnancy, the interplay of testicular and placental hormones as well as local regulatory factors and control by the hypothalamic-pituitary (HP) axis, lead to testicular descent by term. The normal masculine development may be disrupted by environmental factors or genetic defects and result in undescended testes. Minipuberty refers to the postnatal re-activation of the HP-testicular (T) axis after birth. During the first weeks of life, gonadotropin levels increase, followed by activation and proliferation of testicular Leydig, Sertoli and germ cells. Consequent rise in testosterone levels results in penile growth during the first months of life. Testicular size increases and testicular descent continues until three to five months of age. Insufficient HPT axis activation (e.g., hypogonadotropic hypogonadism) is often associated with undescended testis and therefore minipuberty is considered an important phase in the normal male reproductive development. Minipuberty provides a unique window of opportunity for the early evaluation of HPT axis function during early infancy. For cryptorchid boys, hormonal evaluation during minipuberty may give a hint of the underlying etiology and aid in the evaluation of the later risk of HPT axis dysfunction and impaired fertility. The aim of this review is to summarize the current knowledge of the role of minipuberty in testicular development and descent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.