ArticleFrontiers in neuroscience2019
Investigating the Feasibility of Epicranial Cortical Stimulation Using Concentric-Ring Electrodes: A Novel Minimally Invasive Neuromodulation Method.
Article in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Temporal interference stimulation for deep brain neuromodulation in humans.Nature biomedical engineering · 2026Review
- Neuronal effects of epicranial current stimulation in macaque cortex.Frontiers in neuroscience · 2025Article
- Beyond the surface: a review of transcranial temporal interference stimulation for deep brain modulation.Frontiers in neurology · 2025Review
- Focused Epicranial Brain Stimulation by Spatial Sculpting of Pulsed Electric Fields Using High Density Electrode Arrays.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Article
- Frequency-Specific Modulation of Slow-Wave Neural Oscillations via Weak Exogeneous Extracellular Fields Reveals a Resonance Pattern.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Workshops of the Eighth International Brain-Computer Interface Meeting: BCIs: The Next Frontier.Brain computer interfaces (Abingdon, England) · 2022Article
- Collagen/heparan sulfate porous scaffolds loaded with neural stem cells improve neurological function in a rat model of traumatic brain injury.Neural regeneration research · 2021Article
- A Computational Modeling Study to Investigate the Use of Epicranial Electrodes to Deliver Interferential Stimulation to Subcortical Regions.Frontiers in neuroscience · 2021Article
- Animal Models of Tinnitus Treatment: Cochlear and Brain Stimulation.Current topics in behavioral neurosciences · 2021Article
- Cortical stimulation in pharmacoresistant focal epilepsies.Bioelectronic medicine · 2020Review
- Rapid, Dose-Dependent Enhancement of Cerebral Blood Flow by transcranial AC Stimulation in Mouse.Brain stimulationArticle
- Trigeminal nerve direct current stimulation causes sustained increase in neural activity in the rat hippocampus.Brain stimulationArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInvasive cortical stimulation (ICS) is a neuromodulation method in which electrodes are implanted on the cortex to deliver chronic stimulation. ICS has been used to treat neurological disorders such as neuropathic pain, epilepsy, movement disorders and tinnitus. Noninvasive neuromodulation methods such as transcranial magnetic stimulation and transcranial electrical stimulation (TES) show great promise in treating some neurological disorders and require no surgery. However, only acute stimulation can be delivered. Epicranial current stimulation (ECS) is a novel concept for delivering chronic neuromodulation through subcutaneous electrodes implanted on the skull. The use of concentric-ring ECS electrodes may allow spatially focused stimulation and offer a less invasive alternative to ICS.
objectivesDemonstrate ECS proof-of-concept using concentric-ring electrodes in rats and then use a computational model to explore the feasibility and limitations of ECS in humans.
methodsECS concentric-ring electrodes were implanted in 6 rats and pulsatile stimulation delivered to the motor cortex. An MRI based electro-anatomical human head model was used to explore different ECS concentric-ring electrode designs and these were compared with ICS and TES.
resultsConcentric-ring ECS electrodes can selectively stimulate the rat motor cortex. The computational model showed that the concentric-ring ECS electrode design can be optimized to achieve focused cortical stimulation. In general, focality was less than ICS but greater than noninvasive transcranial current stimulation.
conclusionECS could be a promising minimally invasive alternative to ICS. Further work in large animal models and patients is needed to demonstrate feasibility and long-term stability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.