Evidence map›Paper›PMID 31395937›Full record

ArticleScientific reports2019

An Exploratory Radiomics Approach to Quantifying Pulmonary Function in CT Images.

Kyle J Lafata, Zhennan Zhou, Jian-Guo Liu, Julian Hong, Chris R Kelsey, Fang-Fang Yin

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 60 citations in OpenAlex.

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  12. Prognostic value of different discretization parameters inJournal of medical imaging (Bellingham, Wash.) · 2024
    Article
  13. A CT-Based Lung Radiomics Nomogram for Classifying the Severity of Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2024
    Article
  14. Article
  15. Article
  16. Radiomics: a primer on high-throughput image phenotyping.Abdominal radiology (New York) · 2022
    Review
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Kyle J LafataDepartment of Radiation Oncology, Duke University Medical Center, Durham, NC, USA. kyle.lafata@duke.edu.
Zhennan ZhouBeijing International Center of Mathematical Research, Peking University, Beijing, China.ORCID http://orcid.org/0000-0003-4822-0275
Jian-Guo LiuDepartment of Physics, Duke University, Durham, NC, USA.
Julian HongDepartment of Radiation Oncology, Duke University Medical Center, Durham, NC, USA.ORCID http://orcid.org/0000-0001-5172-6889
Chris R KelseyDepartment of Radiation Oncology, Duke University Medical Center, Durham, NC, USA.
Fang-Fang YinDepartment of Radiation Oncology, Duke University Medical Center, Durham, NC, USA. fangfang.yin@duke.edu.
Duke University · USDuke Medical Center · USPeking University · CN

Funding

A Limited-angle Intra-fractional Verification (LIVE) System for SBRT TreatmentsR01CA184173 · NCI · DUKE UNIVERSITY · PI REN, LEI, YIN, FANG-FANG · 2015 to 2018
$1.5M
Motion Management Using 4D-MRI for Liver Cancer in Radiation TherapyR21CA165384 · NCI · DUKE UNIVERSITY · PI CAI, JING, YIN, FANG-FANG · 2013 to 2015
$642k
Image-guided Dosimetry for Injectable Brachytherapy based on Elastin-like Polypeptide NanoparticlesR21CA218940 · NCI · DUKE UNIVERSITY · PI CAI, JING, YIN, FANG-FANG · 2017 to 2018
$365k
NCI NIH HHS R01 CA184173NCI NIH HHS R21 CA165384NCI NIH HHS R21 CA218940
6 · The paper itself

Abstract

Contemporary medical imaging is becoming increasingly more quantitative. The emerging field of radiomics is a leading example. By translating unstructured data (i.e., images) into structured data (i.e., imaging features), radiomics can potentially characterize clinically useful imaging phenotypes. In this paper, an exploratory radiomics approach is used to investigate the potential association between quantitative imaging features and pulmonary function in CT images. Thirty-nine radiomic features were extracted from the lungs of 64 patients as potential imaging biomarkers for pulmonary function. Collectively, these features capture the morphology of the lungs, as well as intensity variations, fine-texture, and coarse-texture of the pulmonary tissue. The extracted lung radiomics data was compared to conventional pulmonary function tests. In general, patients with larger lungs of homogeneous, low attenuating pulmonary tissue (as measured via radiomics) were found to be associated with poor spirometry performance and a lower diffusing capacity for carbon monoxide. Unsupervised dynamic data clustering revealed subsets of patients with similar lung radiomic patterns that were found to be associated with similar forced expiratory volume in one second (FEV

Indexed as

Respiratory Function TestsCarcinoma, Non-Small-Cell LungHumansLung NeoplasmsTomography, X-Ray Computed

Identifiers

PMID31395937
PMCPMC6687824
OpenAlexW2968254627

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.