ArticleScientific reports2019
Antibiotic use during pregnancy and childhood overweight: A population-based nationwide cohort study.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Prevalence of systemic antibacterial use during pregnancy worldwide: A systematic review.PloS one · 2024Pooled it
- Early-life antibiotic exposure and the risk of overweight and obesity in children.Pediatric research · 2026Article
- Early-Life β-Lactam Exposure and the Developing Microbiome: Clinical Relevance and Controversies.Microorganisms · 2026Review
- The landscape of pregnancy and prepregnancy cohorts: a scoping review.BMC pregnancy and childbirth · 2025Article
- Presence of antibiotics in children's urine: a silent risk beyond drinking water.Scientific reports · 2025Article
- Effect of maternal exposure to antibiotics during pregnancy on the neonatal intestinal microbiome and health.Clinical journal of gastroenterology · 2025Review
- Antibiotic Exposure and Childhood Overweight/Obesity: Evidence from Epidemiological and Experimental Studies.Current pharmaceutical design · 2025Review
- In Utero Exposure to Antibiotics and Risk of Serious Infections in the First Year of Life.Drug safety · 2024Article
- Offspring cardiometabolic outcomes and postnatal growth trajectories after exposure to maternal SARS-CoV-2 infection.Obesity (Silver Spring, Md.) · 2024Article
- Review
- Effects of Varied Sulfamethazine Dosage and Exposure Durations on Offspring Mice.Microorganisms · 2024Article
- Scarring the early-life microbiome: its potential life-long effects on human health and diseases.BMB reports · 2023Review
- Prenatal and Perinatal Antibiotic Exposure and Long-Term Outcome.Pediatric gastroenterology, hepatology & nutrition · 2023Review
- Association between maternal antibiotic exposure during pregnancy and childhood obesity in the Japan Environment and Children's Study.Pediatric obesity · 2022Article
- Group B streptococcal infection of the genitourinary tract in pregnant and non-pregnant patients with diabetes mellitus: An immunocompromised host or something more?American journal of reproductive immunology (New York, N.Y. : 1989) · 2021Review
- Effect of exposure to antibiotics on the gut microbiome and biochemical indexes of pregnant women.BMJ open diabetes research & care · 2021Article
- Optimizing drug selection from a prescription trajectory of one patient.NPJ digital medicine · 2021Article
- Do Antibiotics Cause Obesity Through Long-term Alterations in the Gut Microbiome? A Review of Current Evidence.Current obesity reports · 2021Review
- Review
- Exposure to antibiotics and mental disorders in children: a community-based cross-sectional study.Environmental geochemistry and health · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies in mice suggest that early life represents a critical time window, where antibiotics may exert profound and lasting effects on the gut microbiota and metabolism. We aimed to test the hypothesis that prenatal antibiotic exposure is associated with increased risk of childhood overweight in a population-based cohort study. We linked 43,365 mother-child dyads from a nationwide cohort of pregnant women and their offspring to the Danish National Prescription Registry. Linear and logistic regression models were used to examine associations between prenatal exposure to antibiotics and BMI z-score and overweight (including obesity) at age seven and 11 years. Prenatal antibiotic exposure and childhood overweight were both associated with high pre-pregnancy BMI, maternal diabetes, multi-parity, smoking, low socioeconomic status, high paternal BMI, and short duration of breastfeeding. After adjustment for confounders, no associations were observed between prenatal antibiotic exposure and odds of overweight at age seven and 11 years. Whereas no association was observed between broad-spectrum antibiotics and overweight at age 11 years, exposure to broad-spectrum antibiotics was associated with higher odds of overweight at age seven years with an odds ratio of 1.27 (95% CI, 1.05-1.53) for ampicillin and an odds ratio of 1.56 (95% CI, 1.23-1.97) for amoxicillin. As we did not account for underlying infections, the observed associations with early childhood overweight could be explained by confounding by indication. In conclusion, our population-based study suggests that prenatal exposure to narrow-spectrum antibiotics is not associated with overweight in offspring. Exposure to some broad-spectrum antibiotics may increase the odds of overweight in early childhood, but the association does not persist in later childhood.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.